ArticleTissue engineering. Part B, Reviews2017
Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment.
Article in Tissue engineering. Part B, Reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Matrix degradation promotes fibronectin deposition and spatial remodeling in 3D.Cell reports. Physical science · 2026Article
- Review
- pH-responsive printable conductive hydrogels loaded with ApoVs promote diabetic wound repair through oxidative stress scavenging and macrophage reprogramming.Materials today. Bio · 2026Article
- Microfluidics, 3D bioprinted scaffold and organ-on-chip with biosensing activated therapeutic strategies for diabetic wound healing.Frontiers in bioengineering and biotechnology · 2026Review
- Understanding molecular mechanism of diabetic wound healing: addressing recent advancements in therapeutic managements.Journal of diabetes and metabolic disorders · 2025Review
- Fabrication and Characterization of Oxygen-Generating Polylactic Acid/Calcium Peroxide Composite Filaments for Bone Scaffolds.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors.Frontiers in cell and developmental biology · 2021Review
- Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties.Scientific reports · 2020Article
- Hydrogel Production Platform with Dynamic Movement Using Photo-Crosslinkable/Temperature Reversible Chitosan Polymer and Stereolithography 4D Printing Technology.Tissue engineering and regenerative medicine · 2020Article
- Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications.Polymers · 2020Article
- Advances and Future Perspectives in 4D Bioprinting.Biotechnology journal · 2018Review
- Restoring vasculogenic potential of endothelial cells from diabetic patients through spheroid formation.Cellular and molecular bioengineering · 2018Article
- Skin Tissue Substitutes and Biomaterial Risk Assessment and Testing.Frontiers in bioengineering and biotechnology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.
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Registered trials
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