SynthesisEvidence-based mental health2016
Prevalence, impact and treatment of generalised anxiety disorder in bipolar disorder: a systematic review and meta-analysis.
Synthesis in Evidence-based mental health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Pharmacological treatments in panic disorder in adults: a network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- CFTR variants and renal abnormalities in males with congenital unilateral absence of the vas deferens (CUAVD): a systematic review and meta-analysis of observational studies.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Pooled it
- Benzodiazepines versus placebo for panic disorder in adults.The Cochrane database of systematic reviews · 2019Pooled it
- Associations among comorbid anxiety, psychiatric symptomatology, and diabetic control in a population with serious mental illness and diabetes: Findings from an interventional randomized controlled trial.International journal of psychiatry in medicine · 2018Trial
- Early intervention in anxiety disorder patients with clinical high-risk factors for bipolar disorder: A randomized controlled trial.World journal of clinical cases · 2026Article
- Staging of suicidality in bipolar disorder: Findings from the FACE-BD cohort (FondaMental Advanced Centers of Expertise for Bipolar Disorders).European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Untangling the complex relationship between bipolar disorder and anxiety: a comprehensive review of prevalence, prognosis, and therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Challenges in the development of treatment guidelines for bipolar disorder.Frontiers in psychiatry · 2025Article
- The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Dissociative Symptoms and Disorders in Patients With Bipolar Disorders: A Scoping Review.Frontiers in psychiatry · 2022Article
- Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis.Disease markers · 2022Article
- The lifetime prevalence and impact of generalized anxiety disorders in an epidemiologic Italian National Survey carried out by clinicians by means of semi-structured interviews.BMC psychiatry · 2021Article
- Article
- Bipolar depression: a major unsolved challenge.International journal of bipolar disorders · 2020Review
- The Factor Structure of the Mood Disorder Questionnaire in Tunisian Patients.Clinical practice and epidemiology in mental health : CP & EMH · 2020Article
- Depression-/Anxiety-Like Behavior Alterations in Adult Slit2 Transgenic Mice.Frontiers in behavioral neuroscience · 2020Article
- Comorbidity of bipolar and anxiety disorders: An overview of trends in research.World journal of psychiatry · 2019Review
- Mental disorders and suicide risk in emerging adulthood: the 1993 Pelotas birth cohort.Revista de saude publica · 2019Article
- Treatment of anxiety disorders in patients with comorbid bipolar disorder.The mental health clinician · 2018Article
- Bipolar disorder, comorbid anxiety disorders, gynecomastia and dental pain: case analysis with literature review.BJPsych open · 2018Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 5 countries.
Funding
Abstract
questionRecent data suggest that anxiety disorders are as often comorbid with bipolar disorder (BD) as with unipolar depression; however, less attention has been paid to comorbidity of anxiety disorders with BD. Generalised anxiety disorder (GAD) is one of the most prevalent anxiety disorders that is highly comorbid with other mental disorders. We carried out a systematic review and meta-analysis to assess the degree of comorbidity between GAD and BD. STUDY SELECTION AND ANALYSIS: We searched for all studies, which included primary data concerning the existence of GAD in patients with BD. The literature search strategy, selection of publications and the reporting of results have been conducted with PRISMA guidelines. The meta-analysis calculated prevalence estimates using the variance-stabilising Freeman-Tukey double arcsine transformation. We applied the inverse variance method using both fixed-effects and random-effects models to estimate summary effects for all combined studies. Heterogeneity was assessed and measured with Cochran's Q and I(2) statistics, respectively.
findingsThe current meta-analysis analysed data from 28 independent studies and a total of 2975 patients from point prevalence studies and 4919 patients from lifetime studies. The overall random-effects point prevalence of GAD in patients with BD was 12.2% (95% CI 10.9% to 13.5%) and the overall random-effects lifetime estimate was 15.1% (95% CI 9.7% to 21.5%). Both estimates reported significant heterogeneity (94.0% and 94.7%, respectively).
conclusionsPublished studies report prevalence rates with high heterogeneity and consistently higher than those typically reported in the general population. It is believed that comorbid GAD might be associated with a more severe BD course and increased suicidality, and it is unknown how best to treat such conditions. The current meta-analysis confirms that GAD is highly prevalent in BD and the rate is higher in comparison to those in the general population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.