ArticleBMC complementary and alternative medicine2016
Partial characterization and antioxidant and antiproliferative activities of the aqueous extracellular polysaccharides from the thermophilic microalgae Graesiella sp.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 94 citations in OpenAlex.
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- Molecular Characterization and Biocompatibility of Exopolysaccharide Produced by Moderately Halophilic BacteriumPolymers · 2022Article
- Microalgae-derived polysaccharides: Potential building blocks for biomedical applications.World journal of microbiology & biotechnology · 2022Review
- Sustainable microalgal biomass production in food industry wastewater for low-cost biorefinery products: a review.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022Review
- Characterization and Biotechnological Potential of Extracellular Polysaccharides Synthesized byMarine drugs · 2021Article
- Production of Algal Biomass and High-Value Compounds Mediated by Interaction of MicroalgalJournal of microbiology and biotechnology · 2021Article
- Immunomodulatory, Antioxidant Activity and Cytotoxic Effect of Sulfated Polysaccharides fromBiomolecules · 2021Article
- Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy.Frontiers in pharmacology · 2021Review
- Nutritional evaluation and human health-promoting potential of compounds biosynthesized by native microalgae from the Peruvian Amazon.World journal of microbiology & biotechnology · 2020Article
- The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview.Marine drugs · 2019Review
- Microalgae for High-Value Products Towards Human Health and Nutrition.Marine drugs · 2019Review
- Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications.Molecules (Basel, Switzerland) · 2019Review
- In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.BMC complementary and alternative medicine · 2018Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor thousands of years, Tunisian geothermal water has been used in bathing. Indeed, thermal baths "Hammam" were recommended in the treatment of different type of illnesses as, for instance, for relaxing joints and soothing. The ability of microalgae to sustain at the high temperature makes them potential producers of high value thermostable bio-products. This study aimed to explore the therapeutic potential of the aqueous extracellular polysaccharides (AEPS) of the Tunisian thermophilic microalgae Graesiella sp. and to evaluate its physico-chemical characteristics.
methodsDifferent parameters were used to characterize the AEPS. The dry weight, volatile dry weight, elemental analysis, monosaccharide composition and IR-spectroscopy analysis. Carbohydrate, uronic acid, ester sulfate and protein concentrations were also determined using colorimetric assay. AEPS was analyzed for its antioxidant propriety by means of total antioxidant capacity, DPPH radicals scavenging assay, ferrous chelating ability and hydroxyl and superoxide radical scavenging activity. The antiproliferative activity of AEPS was evaluated for HepG2 and Caco-2 cells using the MTT assay.
resultsThe Graesiella sp. AEPS is found to be a hetero-sulfated-anionic polysaccharides that contain carbohydrate (52 %), uronic acids (23 %), ester sulfate (11 %) and protein (12 %). The carbohydrate fraction was formed by eight neutral sugars glucose, galactose, mannose, fucose, rhamnose, xylose, arabinose and ribose. The FT-IR revealed the presence of carboxyl, hydroxyl, amine and sulfate groups. AEPS showed high activity as reducing agent, high ferrous chelating capacity and caused a significant decrease in a concentration-dependent manner of hydroxyl radical. A moderate DPPH scavenging activity and a poor superoxide radical scavenging ability were also observed. AEPS treatment (from 0.01 to 2.5 mg/ml) caused also a clear decrease of cell viabilities in a dose-dependent manner. The IC50 values obtained in HepG2 and Caco-2 cells were 1.06 mg/ml and 0.3 mg/ml respectively.
conclusionsThis study evidenced that the Graesiella sp. AEPS exhibits antioxidant and antiproliferative activities. The biological activities of this extract depend on its fine structural features. Further work will identify and purify the active polysaccharides to enhance our understanding of their complete structure and relationships with its function.
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