ArticleNature communications2016
αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed, 48 citations in OpenAlex.
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Kdf1 missense mutation caused enamel defects by disrupting cell adhesion and Hippo-YAP signaling in dental epithelium.International journal of oral science · 2026Article
- Integrated Genetic Networks and Epigenetic Regulation inTooth Development and Maturation.Cells · 2026Review
- Spatiotemporal Molecular Architecture of Lineage Allocation and Cellular Organization in Tooth Morphogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement.PLoS genetics · 2024Article
- Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development.Nature cell biology · 2024Article
- Exosomes derived from adipose tissues accelerate fibroblasts and keratinocytes proliferation and cutaneous wound healing via miR-92a/Hippo-YAP axis.Journal of physiology and biochemistry · 2024Article
- Article
- Emerging Roles of YAP/TAZ in Tooth and Surrounding: from Development to Regeneration.Stem cell reviews and reports · 2023Review
- Tooth number abnormality: from bench to bedside.International journal of oral science · 2023Review
- Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis.Frontiers in cell and developmental biology · 2023Review
- Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo.Science signaling · 2022Article
- Understanding the development of oral epithelial organs through single cell transcriptomic analysis.Development (Cambridge, England) · 2022Article
- Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP.Targeted oncology · 2022Review
- Parallels in signaling between development and regeneration in ectodermal organs.Current topics in developmental biology · 2022Article
- Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs.Drug design, development and therapy · 2022Article
- Chromosomal neighbourhoods allow identification of organ specific changes in gene expression.PLoS computational biology · 2021Article
- The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche.Stem cells (Dayton, Ohio) · 2021Article
- From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues.Biomolecules · 2021Review
- The initiation knot is a signaling center required for molar tooth development.Development (Cambridge, England) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
Embryonic signalling centres are specialized clusters of non-proliferating cells that direct the development of many organs. However, the mechanisms that establish these essential structures in mammals are not well understood. Here we report, using the murine incisor as a model, that αE-catenin is essential for inhibiting nuclear YAP localization and cell proliferation. This function of αE-catenin is required for formation of the tooth signalling centre, the enamel knot (EK), which maintains dental mesenchymal condensation and epithelial invagination. EK formation depends primarily on the signalling function of αE-catenin through YAP and its homologue TAZ, as opposed to its adhesive function, and combined deletion of Yap and Taz rescues the EK defects caused by loss of αE-catenin. These findings point to a developmental mechanism by which αE-catenin restricts YAP/TAZ activity to establish a group of non-dividing and specialized cells that constitute a signalling centre.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.