ArticleSocial cognitive and affective neuroscience2016
Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.Biological psychiatry · 2018Pooled it
- Childhood abuse moderates the impact of serum BDNF on short- and long-term antidepressant response.European child & adolescent psychiatry · 2026Article
- Disrupted rich club organization in structural brain networks is related to childhood maltreatment in major depressive disorder.Frontiers in psychiatry · 2026Article
- Socioeconomic factors, brain-derived neurotrophic factor Val66Met polymorphism, and cortical structure in children and adolescents.Scientific reports · 2025Article
- The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity.Brain, behavior, & immunity - health · 2024Article
- Reconsidering the nature of threat in infancy: Integrating animal and human studies on neurobiological effects of infant stress.Neuroscience and biobehavioral reviews · 2024Review
- Interplay between stress, sleep, and BDNF in a high-risk sample of young adults.Scientific reports · 2023Article
- Greater maltreatment severity is associated with smaller brain volume with implication for intellectual ability in young children.Neurobiology of stress · 2023Article
- Long-term effects of childhood trauma subtypes on adult brain function.Brain and behavior · 2023Article
- Experience-dependent associations between distinct subtypes of childhood trauma and brain function and architecture.Quantitative imaging in medicine and surgery · 2022Article
- Default Mode Network Alterations Induced by Childhood Trauma Correlate With Emotional Function and SLC6A4 Expression.Frontiers in psychiatry · 2021Article
- Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study.Brain and behavior · 2020Article
- Brain-derived neurotrophic factor association with amygdala response in major depressive disorder.Journal of affective disorders · 2020Article
- Article
- Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness.Scientific reports · 2019Article
- Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma.Frontiers in psychiatry · 2019Review
- Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation.Frontiers in psychiatry · 2019Review
- Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response.Psychological medicine · 2018Article
- Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers.Frontiers in human neuroscience · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood maltreatment (CM) has been associated with altered brain morphology, which may partly be due to a direct impact on neural growth, e.g. through the brain-derived neurotrophic factor (BDNF) pathway. Findings on CM, BDNF and brain volume are inconsistent and have never accounted for the entire BDNF pathway. We examined the effects of CM, BDNF (genotype, gene expression and protein level) and their interactions on hippocampus, amygdala and anterior cingulate cortex (ACC) morphology. Data were collected from patients with depression and/or an anxiety disorder and healthy subjects within the Netherlands Study of Depression and Anxiety (NESDA) (N = 289). CM was assessed using the Childhood Trauma Interview. BDNF Val66Met genotype, gene expression and serum protein levels were determined in blood and T1 MRI scans were acquired at 3T. Regional brain morphology was assessed using FreeSurfer. Covariate-adjusted linear regression analyses were performed. Amygdala volume was lower in maltreated individuals. This was more pronounced in maltreated met-allele carriers. The expected positive relationship between BDNF gene expression and volume of the amygdala is attenuated in maltreated subjects. Finally, decreased cortical thickness of the ACC was identified in maltreated subjects with the val/val genotype. CM was associated with altered brain morphology, partly in interaction with multiple levels of the BNDF pathway. Our results suggest that CM has different effects on brain morphology in met-carriers and val-homozygotes and that CM may disrupt the neuroprotective effect of BDNF.
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