ArticleScientific reports2016
Effects of Fluoroquinolones and Azithromycin on Biofilm Formation of Stenotrophomonas maltophilia.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Contemporary management considerations of urinary tract infections for women with spina bifida.International urogynecology journal · 2022Pooled it
- Phenotypic and genomic insights into Stenotrophomonas sepilia SMBL8: metabolic versatility, antibiotic resistance and pathogenic potential.World journal of microbiology & biotechnology · 2026Article
- Antimicrobial resistance mechanisms, treatment challenges, and emerging strategies inFrontiers in cellular and infection microbiology · 2026Review
- StM171, aViruses · 2023Article
- In vitro synergy screens of FDA-approved drugs reveal novel zidovudine- and azithromycin-based combinations with last-line antibiotics against Klebsiella pneumoniae.Scientific reports · 2023Article
- Article
- Comparative genomics analysis ofFrontiers in cellular and infection microbiology · 2023Article
- Effect of pH-sensitive nanoparticles on inhibiting oral biofilms.Drug delivery · 2022Article
- The effect of fluoroquinolones and antioxidans on biofilm formation by Proteus mirabilis strains.Annals of clinical microbiology and antimicrobials · 2022Article
- Clinical challenges treatingJAC-antimicrobial resistance · 2022Review
- In vitro Antibacterial Activity and Resistance Prevention of Antimicrobial Combinations for Dihydropteroate Synthase-CarryingInfection and drug resistance · 2022Article
- Advances in the Microbiology of Stenotrophomonas maltophilia.Clinical microbiology reviews · 2021Article
- Antibiotic resistance, biofilm formation, and biofilm-associated genes among Stenotrophomonas maltophilia clinical isolates.BMC research notes · 2021Article
- Exposure of Salmonella biofilms to antibiotic concentrations rapidly selects resistance with collateral tradeoffs.NPJ biofilms and microbiomes · 2021Article
- Effects of Simulated Microgravity on the Physiology ofFrontiers in microbiology · 2021Article
- Effects of Tigecycline Combined with Azithromycin Against Biofilms of Multidrug-ResistantInfection and drug resistance · 2021Article
- Article
- Modulated Response ofFrontiers in cellular and infection microbiology · 2020Article
- In-vitro Investigation of Antibiotics Efficacy Against UropathogenicInfection and drug resistance · 2020Article
- Heterogeneous Colistin-Resistance Phenotypes Coexisting inFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stenotrophomonas maltophilia is an opportunistic pathogen that causes respiratory and urinary tract infections, as well as wound infections in immunocompromised patients. This pathogen is difficult to treat due to increased resistance to many antimicrobial agents. We investigated the in vitro biofilm formation of S. maltophilia, including effects of fluoroquinolones (FQs) and azithromycin on biofilm formation. The organism initiated attachment to polystyrene surfaces after a 4 h incubation period, and reached maximal growth at 18-24 h. In the presence of FQs (moxifloxacin, levofloxacin or ciprofloxacin), the biofilm biomass was significantly reduced (P < 0.05). A lower concentration of moxifloxacin (10 μg/mL) exhibited a better inhibiting effect on biofilm formation than 100 μg/mL (P < 0.01), but with no difference in effect compared to the 50 μg/mL concentration (P > 0.05). However, the inhibitory effects of 10 μg/mL of levofloxacin or ciprofloxacin were slightly less pronounced than those of the higher concentrations. A combination of azithromycin and FQs significantly reduced the biofilm inhibiting effect on S. maltophilia preformed biofilms compared to azithromycin or FQs alone. We conclude that early use of clinically acceptable concentrations of FQs, especially moxifloxacin (10 μg/mL), may possibly inhibit biofilm formation by S. maltophilia. Our study provides an experimental basis for a possible optimal treatment strategy for S. maltophilia biofilm-related infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.