ArticleEnvironmental health perspectives2017
Polybrominated Diphenyl Ethers in Human Milk and Serum from the U.S. EPA MAMA Study: Modeled Predictions of Infant Exposure and Considerations for Risk Assessment.
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Has Regulatory Action Reduced Human Exposure to Flame Retardants?Environmental science & technology · 2023Pooled it
- Fetal exposure to persistent organic pollutants and childhood autism risk.Environmental research · 2026Article
- Polybrominated Diphenyl Ether (PBDE) Serum Concentrations in Italian Women of Reproductive Age.Toxics · 2026Article
- Beyond Infections: Exploring Immune-Mediated Pathways Linking Cannabis and Emerging Environmental Contaminants to Neurodevelopmental Outcomes.Advances in experimental medicine and biology · 2025Review
- Maternal probiotic supplementation protects against PBDE-induced developmental, behavior and metabolic reprogramming in a sexually dimorphic manner: Role of gut microbiome.Archives of toxicology · 2025Article
- Prenatal exposure to polybrominated diphenyl ether (PBDE) and child neurodevelopment: The role of breastfeeding duration.The Science of the total environment · 2024Article
- Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data.Environment international · 2023Article
- Perspective: Human Milk Composition and Related Data for National Health and Nutrition Monitoring and Related Research.Advances in nutrition (Bethesda, Md.) · 2022Article
- GSTT1, an increased risk factor for prostate cancer in patients with metabolic syndrome.Journal of clinical laboratory analysis · 2022Article
- Current Breast Milk PFAS Levels in the United States and Canada: After All This Time, Why Don't We Know More?Environmental health perspectives · 2022Article
- Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice.Drug metabolism and disposition: the biological fate of chemicals · 2019Article
- Temporal trends in serum polybrominated diphenyl ether concentrations in the Australian population, 2002-2013.Environment international · 2018Article
- Environmental Chemicals in Breast Milk and Formula: Exposure and Risk Assessment Implications.Environmental health perspectives · 2018Review
- Chemical Contaminants in Raw and Pasteurized Human Milk.Journal of human lactation : official journal of International Lactation Consultant Association · 2018Article
- Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSerum concentrations of polybrominated diphenyl ethers (PBDEs) in U.S. women are believed to be among the world's highest; however, little information exists on the partitioning of PBDEs between serum and breast milk and how this may affect infant exposure.
objectivesPaired milk and serum samples were measured for PBDE concentrations in 34 women who participated in the U.S. EPA MAMA Study. Computational models for predicting milk PBDE concentrations from serum were evaluated.
methodsSamples were analyzed using gas chromatography isotope-dilution high-resolution mass spectrometry. Observed milk PBDE concentrations were compared with model predictions, and models were applied to NHANES serum data to predict milk PBDE concentrations and infant intakes for the U.S. population.
resultsSerum and milk samples had detectable concentrations of most PBDEs. BDE-47 was found in the highest concentrations (median serum: 18.6; milk: 31.5 ng/g lipid) and BDE-28 had the highest milk:serum partitioning ratio (2.1 ± 0.2). No evidence of depuration was found. Models demonstrated high reliability and, as of 2007-2008, predicted U.S. milk concentrations of BDE-47, BDE-99, and BDE-100 appear to be declining but BDE-153 may be rising. Predicted infant intakes (ng/kg/day) were below threshold reference doses (RfDs) for BDE-99 and BDE-153 but above the suggested RfD for BDE-47.
conclusionsConcentrations and partitioning ratios of PBDEs in milk and serum from women in the U.S. EPA MAMA Study are presented for the first time; modeled predictions of milk PBDE concentrations using serum concentrations appear to be a valid method for estimating PBDE exposure in U.S. infants.
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