ArticleScientific reports2016
The role of dimensionality in neuronal network dynamics.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Electrophysiological features of cortical 3D networks are deeply modulated by scaffold properties.APL bioengineering · 2024Article
- Impact of Magnetite Nanowires on In Vitro Hippocampal Neural Networks.Biomolecules · 2023Article
- Modeling the three-dimensional connectivity of in vitro cortical ensembles coupled to Micro-Electrode Arrays.PLoS computational biology · 2023Article
- Emergent structural and functional properties of hippocampal multi-cellular aggregates.Frontiers in neuroscience · 2023Article
- The mechanical, optical, and thermal properties of graphene influencing its pre-clinical use in treating neurological diseases.Frontiers in neuroscience · 2023Review
- A Three-Dimensional Primary Cortical Culture System Compatible with Transgenic Disease Models, Virally Mediated Fluorescence, and Live Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Review
- Two-dimensional TiJournal of nanobiotechnology · 2022Article
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- Epidemic models characterize seizure propagation and the effects of epilepsy surgery in individualized brain networks based on MEG and invasive EEG recordings.Scientific reports · 2022Article
- Application of Graphene in Tissue Engineering of the Nervous System.International journal of molecular sciences · 2021Review
- Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip.In vitro cellular & developmental biology. Animal · 2021Review
- Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology.Micromachines · 2021Review
- Establishment of Long-Term Primary Cortical Neuronal Cultures From Neonatal OpossumFrontiers in cellular neuroscience · 2021Article
- 3-D multi-electrode arrays detect early spontaneous electrophysiological activity in 3-D neuronal-astrocytic co-cultures.Biomedical engineering letters · 2020Article
- Functional Characterization of Three-Dimensional Cortical Cultures for In Vitro Modeling of Brain Networks.iScience · 2020Article
- The Emergence of Integrated Information, Complexity, and 'Consciousness' at Criticality.Entropy (Basel, Switzerland) · 2020Article
- Impact of Physical Obstacles on the Structural and Effective Connectivity ofFrontiers in computational neuroscience · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent results from network theory show that complexity affects several dynamical properties of networks that favor synchronization. Here we show that synchronization in 2D and 3D neuronal networks is significantly different. Using dissociated hippocampal neurons we compared properties of cultures grown on a flat 2D substrates with those formed on 3D graphene foam scaffolds. Both 2D and 3D cultures had comparable glia to neuron ratio and the percentage of GABAergic inhibitory neurons. 3D cultures because of their dimension have many connections among distant neurons leading to small-world networks and their characteristic dynamics. After one week, calcium imaging revealed moderately synchronous activity in 2D networks, but the degree of synchrony of 3D networks was higher and had two regimes: a highly synchronized (HS) and a moderately synchronized (MS) regime. The HS regime was never observed in 2D networks. During the MS regime, neuronal assemblies in synchrony changed with time as observed in mammalian brains. After two weeks, the degree of synchrony in 3D networks decreased, as observed in vivo. These results show that dimensionality determines properties of neuronal networks and that several features of brain dynamics are a consequence of its 3D topology.
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Registered trials
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