ArticleScientific reports2016
Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Application of Graph Theory for Identifying Connectivity Patterns in Human Brain Networks: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis.Frontiers in immunology · 2019Trial
- Brain network alterations in autoimmune diseases: Current status and future prospects.iScience · 2026Review
- Spatial gene expression and functional network abnormalities in multiple sclerosis: exploring biological influence on brain functional reorganization.Translational psychiatry · 2026Article
- Integrated brain connectivity analysis with fMRI, DTI, and sMRI powered by interpretable graph neural networks.Medical image analysis · 2025Article
- Article
- Complexity of intrinsic brain activity in relapsing-remitting multiple sclerosis patients: patterns, association with structural damage, and clinical disability.La Radiologia medica · 2025Observational
- Dynamic Changes in Long-Standing Multiple Sclerosis Revealed by Longitudinal Structural Network Analysis Using Diffusion Tensor Imaging.AJNR. American journal of neuroradiology · 2024Article
- Genetic architecture of the structural connectome.Nature communications · 2024Article
- Conservation of structural brain connectivity in people with multiple sclerosis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Graph-Based Analysis of Brain Connectivity in Multiple Sclerosis Using Functional MRI: A Systematic Review.Brain sciences · 2023Review
- An investigation of the association between focal damage and global network properties in cognitively impaired and cognitively preserved patients with multiple sclerosis.Frontiers in neuroscience · 2023Article
- Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample.Development and psychopathology · 2022Article
- Applying multilayer analysis to morphological, structural, and functional brain networks to identify relevant dysfunction patterns.Network neuroscience (Cambridge, Mass.) · 2022Article
- Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: A review.NeuroImage · 2022Review
- The effect of lesion filling on brain network analysis in multiple sclerosis using structural magnetic resonance imaging.Insights into imaging · 2022Article
- Disrupted structural network of inferomedial temporal regions in relapsing-remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder.Scientific reports · 2022Article
- Microstructure-Weighted Connectomics in Multiple Sclerosis.Brain connectivity · 2022Review
- The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics.NeuroImage. Clinical · 2022Review
- Task-based functional MRI challenges in clinical neuroscience: Choice of the best head motion correction approach in multiple sclerosis.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain connectome of multiple sclerosis (MS) has been investigated by several previous studies; however, it is still unknown how the network changes in clinically isolated syndrome (CIS), the earliest stage of MS, and how network alterations on a functional level relate to the structural level in MS disease. Here, we investigated the topological alterations of both the structural and functional connectomes in 41 CIS and 32 MS patients, compared to 35 healthy controls, by combining diffusion tensor imaging and resting-state functional MRI with graph analysis approaches. We found that the structural connectome showed a deviation from the optimal pattern as early as the CIS stage, while the functional connectome only showed local changes in MS patients, not in CIS. When comparing two patient groups, the changes appear more severe in MS. Importantly, the disruptions of structural and functional connectomes in patients occurred in the same direction and locally correlated in sensorimotor component. Finally, the extent of structural network changes was correlated with several clinical variables in MS patients. Together, the results suggested early disruption of the structural brain connectome in CIS patients and provided a new perspective for investigating the relationship of the structural and functional alterations in MS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.