ArticleeLife2016
The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
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- Comprehensive mapping of Epithelial NaBrain structure & function · 2024Article
- Autism risk geneFrontiers in cellular neuroscience · 2024Article
- The epithelial NaCell reports · 2023Article
- The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling.Nature communications · 2023Article
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- Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance ineLife · 2022Article
- Non-Canonical Roles of Apoptotic Caspases in the Nervous System.Frontiers in cell and developmental biology · 2022Review
- Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS.Nature reviews. Neuroscience · 2021Review
- Effect of the protease plasmin onmicroPublication biology · 2021Article
- DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs.The Journal of general physiology · 2021Article
- Open Frontiers in Neural Cell Type Investigations; Lessons FromFrontiers in neuroscience · 2021Review
- Development of specialized sensory neurons engages a nuclear receptor required for functional plasticity.Genes & development · 2020Article
- GABAergic motor neurons bias locomotor decision-making in C. elegans.Nature communications · 2020Article
- WNT regulates programmed muscle remodeling through PLC-β and calcineurin inDevelopment (Cambridge, England) · 2020Article
- Physiological functions of non-apoptotic caspase activity in the nervous system.Seminars in cell & developmental biology · 2018Review
- Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8.American journal of physiology. Cell physiology · 2018Article
- Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans.Current opinion in neurobiology · 2018Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
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Abstract
Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C. elegans Degenerin/Epithelial Sodium Channel (DEG/ENaC) protein, UNC-8, is transcriptionally controlled to function as a trigger in an activity-dependent mechanism that removes synapses in remodeling GABAergic neurons. UNC-8 cation channel activity promotes disassembly of presynaptic domains in DD type GABA neurons, but not in VD class GABA neurons where unc-8 expression is blocked by the COUP/TF transcription factor, UNC-55. We propose that the depolarizing effect of UNC-8-dependent sodium import elevates intracellular calcium in a positive feedback loop involving the voltage-gated calcium channel UNC-2 and the calcium-activated phosphatase TAX-6/calcineurin to initiate a caspase-dependent mechanism that disassembles the presynaptic apparatus. Thus, UNC-8 serves as a link between genetic and activity-dependent pathways that function together to promote the elimination of GABA synapses in remodeling neurons.
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