ArticlePloS one2016
Time Varying Apparent Volume of Distribution and Drug Half-Lives Following Intravenous Bolus Injections.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The FDA's New Guideline "Generally Accepted Scientific Knowledge" (GASK): An Opportunity to Expedite the Approval of Biosimilars.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Chemotherapy and Anticancer Drugs Adjustment in Obesity: A Narrative Review.Current medicinal chemistry · 2023Review
- A series acceleration algorithm for the gamma-Pareto (type I) convolution and related functions of interest for pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Scientific Rationale for Waiving Clinical Efficacy Testing of Biosimilars.Drug design, development and therapy · 2022Article
- Computational approach towards the design of artemisinin-thymoquinone hybrids against main protease of SARS-COV-2.Future journal of pharmaceutical sciences · 2021Article
- Comparison of Performance of Improved Serum Estimators of Glomerular Filtration Rate (GFR) toJournal of nuclear medicine technology · 2017Article
- A gamma-distribution convolution model ofEJNMMI physics · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a model that generalizes the apparent volume of distribution and half-life as functions of time following intravenous bolus injection. This generalized model defines a time varying apparent volume of drug distribution. The half-lives of drug remaining in the body vary in time and become longer as time elapses, eventually converging to the terminal half-life. Two example fit models were substituted into the general model: biexponential models from the least relative concentration error, and gamma variate models using adaptive regularization for least relative error of clearance. Using adult population parameters from 41 studies of the renal glomerular filtration marker 169Yb-DTPA, simulations of extracellular fluid volumes of 5, 10, 15 and 20 litres and plasma clearances of 40 and 100 ml/min were obtained. Of these models, the adaptively obtained gamma variate models had longer times to 95% of terminal volume and longer half-lives.
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