Evidence map›Paper›PMID 27403598›Full record

ArticleEpigenetics2016

Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.

Semira Gonseth, Adam J de Smith, Ritu Roy, Mi Zhou, Seung-Tae Lee, Xiaorong Shao, Juhi Ohja, Margaret R Wrensch, Kyle M Walsh, Catherine Metayer and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Pre- and Postnatal Exposures to Tobacco Smoking and Survival of Childhood Acute Lymphoblastic and Myeloid Leukemias in California, United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Semira Gonsetha Department of Epidemiology and Biostatistics , Laboratory for Molecular Epidemiology, University of California, San Francisco , San Francisco , CA , USA.
Adam J de Smithb The Center for Integrative Research on Childhood Leukemia and the Environment, University of California, Berkeley , Berkeley , CA , USA.
Ritu Royd Computational Biology Core, HDF Comprehensive Cancer Center, University of California, San Francisco , San Francisco , CA , USA.
Mi Zhoub The Center for Integrative Research on Childhood Leukemia and the Environment, University of California, Berkeley , Berkeley , CA , USA.
Seung-Tae Leef Department of Laboratory Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.
Xiaorong Shaob The Center for Integrative Research on Childhood Leukemia and the Environment, University of California, Berkeley , Berkeley , CA , USA.
Juhi Ohjab The Center for Integrative Research on Childhood Leukemia and the Environment, University of California, Berkeley , Berkeley , CA , USA.
Margaret R Wrenschi Department of Neurological Surgery , University of California, San Francisco , San Francisco , CA , USA.
Kyle M Walshb The Center for Integrative Research on Childhood Leukemia and the Environment, University of California, Berkeley , Berkeley , CA , USA.
Catherine Metayerb The Center for Integrative Research on Childhood Leukemia and the Environment, University of California, Berkeley , Berkeley , CA , USA.
Joseph L Wiemelsb The Center for Integrative Research on Childhood Leukemia and the Environment, University of California, Berkeley , Berkeley , CA , USA.
University of California, San Francisco · USUniversity of California, Berkeley · USBerkeley Public Health Division · USNeurological Surgery · USUCSF Helen Diller Family Comprehensive Cancer Center · USYonsei University · KR

Funding

Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
Genome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1M
Project 3 - Prenatal Exposures, Constitutive Genetics, DNA Methylation & Childhood LeukemiaP50ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2015 to 2019
$3.8M
Project 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7M
NCI NIH HHS R01 CA155461NIEHS NIH HHS P01 ES018172NIEHS NIH HHS P50 ES018172NIEHS NIH HHS R01 ES009137
6 · The paper itself

Abstract

Epigenome-wide DNA methylation association studies have identified highly replicable genomic loci sensitive to maternal smoking during gestation. The role of inter-individual genetic variation in influencing DNA methylation, leading to the possibility of confounding or bias of such associations, has not been assessed. We investigated whether the DNA methylation levels at the top 10 CpG sites previously associated with exposure to maternal smoking during gestation were associated with individual genetic variation at the genome-wide level. Genome-wide association tests between DNA methylation at the top 10 candidate CpG and genome-wide SNPs were performed in 736 case and control participants of the California Childhood Leukemia Study. Three of the strongest maternal-smoking sensitive CpG sites in newborns were significantly associated with SNPs located proximal to each gene: cg18146737 in the GFI1 gene with rs141819830 (P = 8.2×10

Indexed as

DNA MethylationEpigenesis, GeneticPolymorphism, Single NucleotideBasic Helix-Loop-Helix ProteinsCase-Control StudiesChild, PreschoolCpG IslandsDNA-Binding ProteinsFemaleGenome-Wide Association StudyHumansInfant, NewbornMaleMinor Histocompatibility AntigensMyosinsPregnancyAHRR protein, humanBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsGFI1 protein, humanMinor Histocompatibility AntigensMYO1G protein, humanMyosinsRepressor ProteinsTranscription FactorsBiological markersDNA methylationgeneticsprenatal exposure delayed effectssmoking

Identifiers

PMID27403598
PMCPMC5048731
OpenAlexW2460278139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.