ArticleTheScientificWorldJournal
Identification of Genes Coding Aminoglycoside Modifying Enzymes in E. coli of UTI Patients in India.
Article in TheScientificWorldJournal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis.The Journal of antimicrobial chemotherapy · 2022Trial
- Sensitivity and resistance pattern of uropathogens causing urinary tract infections among adults at a teaching hospital in South India - A retrospective analysis.Journal of family medicine and primary care · 2025Article
- Phenotypic and genotypic evaluation of aminoglycoside resistance inIranian journal of microbiology · 2024Article
- Cefotaxime/sulbactam plus gentamicin as a potential carbapenem- and amikacin-sparing first-line combination for neonatal sepsis in high ESBL prevalence settings.The Journal of antimicrobial chemotherapy · 2023Article
- The prevalence and distribution of aminoglycoside resistance genes.Biosafety and health · 2023Review
- Evaluation of phenotypic and genotypic patterns of aminoglycoside resistance in the Gram-negative bacteria isolates collected from pediatric and general hospitals.Molecular and cellular pediatrics · 2022Article
- Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness ofFrontiers in microbiology · 2021Article
- The First Saudi Study Investigating the Plasmid-borne Aminoglycoside and Sulfonamide Resistance amongInfection and drug resistance · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study is to probe the pattern of antibiotic resistance against aminoglycosides and its mechanism in E. coli obtained from patients from Chennai, India. Isolation and identification of pathogens were done on MacConkey agar. Antimicrobial sensitivity testing was done by disc diffusion test. The identification of genes encoding aminoglycoside modifying enzymes was done by Polymerase Chain Reaction (PCR). Out of 98 isolates, 71 (72.45%) isolates were identified as E. coli and the remaining 27 (27.55%) as other bacteria. Disc diffusion method results showed a resistance level of 72.15% for streptomycin, 73.4% for gentamicin, 63.26% for neomycin, 57.14% for tobramycin, 47.9% for netilmicin, and 8.16% for amikacin in E. coli. PCR screening showed the presence of four genes, namely, rrs, aacC2, aacA-aphD, and aphA3, in their plasmid DNA. The results point towards the novel mechanism of drug resistance in E. coli from UTI patients in India as they confirm the presence of genes encoding enzymes that cause resistance to aminoglycoside drugs. This could be an alarm for drug prescription to UTI patients.
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