Evidence map›Paper›PMID 27403447›Full record

ArticleNeurophotonics2016

Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods.

Sergio Fantini, Angelo Sassaroli, Kristen T Tgavalekos, Joshua Kornbluth

Open access · bronzeAbstract read
In one paragraph

Article in Neurophotonics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 6 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 6 syntheses or guidelines pooled it, 381 citations in OpenAlex.

  1. Pooled it
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  3. KFrontiers in neurology · 2024
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  14. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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  16. Article
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  18. Observational
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154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sergio FantiniTufts University , Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
Angelo SassaroliTufts University , Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
Kristen T TgavalekosTufts University , Department of Biomedical Engineering, 4 Colby Street, Medford, Massachusetts 02155, United States.
Joshua KornbluthTufts University School of Medicine , Department of Neurology, Division of Neurocritical Care, 800 Washington Street, Box #314, Boston, Massachusetts 02111, United States.
Tufts University · US

Funding

Near-infrared spectral imaging of the breast for cancer detection and monitoringR01CA154774 · NCI · TUFTS UNIVERSITY MEDFORD · PI FANTINI, SERGIO · 2011 to 2015
$2.2M
NCI NIH HHS R01 CA154774
6 · The paper itself

Abstract

Cerebral blood flow (CBF) and cerebral autoregulation (CA) are critically important to maintain proper brain perfusion and supply the brain with the necessary oxygen and energy substrates. Adequate brain perfusion is required to support normal brain function, to achieve successful aging, and to navigate acute and chronic medical conditions. We review the general principles of CBF measurements and the current techniques to measure CBF based on direct intravascular measurements, nuclear medicine, X-ray imaging, magnetic resonance imaging, ultrasound techniques, thermal diffusion, and optical methods. We also review techniques for arterial blood pressure measurements as well as theoretical and experimental methods for the assessment of CA, including recent approaches based on optical techniques. The assessment of cerebral perfusion in the clinical practice is also presented. The comprehensive description of principles, methods, and clinical requirements of CBF and CA measurements highlights the potentially important role that noninvasive optical methods can play in the assessment of neurovascular health. In fact, optical techniques have the ability to provide a noninvasive, quantitative, and continuous monitor of CBF and autoregulation.

Indexed as

autoregulationCerebral perfusioncoherent hemodynamics spectroscopycomputed tomography perfusiondiffuse correlation spectroscopylaser Doppler flowmetrynear-infrared spectroscopyperfusion magnetic resonance imagingtranscranial Doppler

Identifiers

PMID27403447
PMCPMC4914489
OpenAlexW2473533512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.