ArticleUnited European gastroenterology journal2016
Characteristics of chronic megacolon among patients diagnosed with multiple endocrine neoplasia type 2B.
Article in United European gastroenterology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Megacolon Associated with Multiple Endocrine Neoplasia Type 2B: A Case Successfully Managed with Ileostomy.Surgical case reports · 2026Article
- Article
- 3 in 1: Manifestations of Multiple Endocrine Neoplasia Type 2B on Imaging.JCEM case reports · 2025Article
- Multiple endocrine neoplasia type 2B diagnosed after small intestinal volvulus with progressive megacolon in an adolescent.Clinical journal of gastroenterology · 2024Article
- Cystic ovarian teratoma as a novel tumor and growth hormone deficiency as a new condition presenting in Multiple Endocrine Neoplasia type 2B: Case reports and review of the literature.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2022Review
- Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: a case series.Endocrine · 2021Article
- Late diagnosis of metastatic pheochromocytoma in multiple endocrine neoplasia 2B with rapid clinical decline.BMJ case reports · 2021Article
- A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a NewCase reports in endocrinology · 2020Article
- Familial chronic megacolon presenting in childhood or adulthood: Seeking the presumed gene association.Neurogastroenterology and motility · 2019Article
- Constipation with megacolon in a 36-year-old man: a rare presentation of MEN2B from Sri Lanka.BMJ case reports · 2019Article
- Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders.Nature reviews. Gastroenterology & hepatology · 2018Review
- Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa.World journal of gastrointestinal pathophysiology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal symptoms are frequent in multiple endocrine neoplasia (MEN) 2B and may be related to megacolon.
objectiveThe objective of this article is to review the clinical features of patients with MEN 2B, particularly megacolon.
methodsWe used natural language processing of electronic medical records of Mayo Clinic patients over 20 years: Eight patients with definite MEN 2B were identified; of these, four had megacolon. From these patients' records, three others with paper medical records were identified through familial association. We used a standard data sheet to identify features of the disease with particular emphasis on megacolon.
resultsOf the 11 patients identified with MEN 2B, seven (63%) had megacolon, typically presenting with constipation in infancy or megacolon in childhood. In addition, three patients had esophageal manifestations (two achalasia and one Zenker's diverticulum). Megacolon often required surgical intervention for intractable constipation, abdominal distension and discomfort. Histopathological features of resected colon revealed enteric and extrinsic nerve hyperplasia and ganglioneuromas of the submucosal and myenteric plexuses.
conclusionsAmong patients with MEN 2B, 63% had megacolon. Significant esophageal motor disorders in MEN 2B may affect ∼25% of patients. Any presentation with megacolon should trigger a search for MEN 2B in order to identify the potentially fatal endocrine tumors.
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