ArticleUnited European gastroenterology journal2016
Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population.
Article in United European gastroenterology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- Trial
- Associations between psychological factors and functional dyspepsia symptoms with consideration of gender differences.Scientific reports · 2026Article
- Diagnosis of Functional Dyspepsia and Novel Gastrointestinal Functional Assessments.Digestion · 2026Review
- Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study.JMIR research protocols · 2026Article
- Vietnam Association of Gastroenterology (VNAGE) guideline on the management of gastroesophageal reflux disease.Frontiers in medicine · 2026Review
- Drug Survival of Drugs Recommended for Irritable Bowel Syndrome: A Retrospective Observational Study.Neurogastroenterology and motility · 2025Observational
- Overlapping Reflux Symptoms in Functional Dyspepsia Are Mostly Unrelated to Gastroesophageal Reflux.Journal of neurogastroenterology and motility · 2025Article
- Characteristics and Risk Factors of Functional Dyspepsia Fulfilling the Rome IV Criteria Overlapping With Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China.Journal of neurogastroenterology and motility · 2024Article
- Clinical factors associated with stable treatment of chronic constipation in Japanese patients.BMC gastroenterology · 2024Article
- Review of the Patient Burden and Therapeutic Landscape of Irritable Bowel Syndrome with Constipation in the United States.Clinical and experimental gastroenterology · 2024Review
- Esophageal Reflux Hypersensitivity: A Comprehensive Review.Gut and liver · 2023Review
- Work productivity and activity impairment in disorders of gut-brain interaction: Data from the Rome Foundation Global Epidemiology Study.United European gastroenterology journal · 2023Article
- Understanding and managing patients with overlapping disorders of gut-brain interaction.The lancet. Gastroenterology & hepatology · 2023Review
- Unrecognized Functional Dyspepsia Among Those With Refractory Chronic Constipation: Analysis of a Tertiary Cohort.Gastro hep advances · 2023Article
- Comparison of the effects of individual symptoms of gastroesophageal reflux disease co-existing functional dyspepsia on patients' daily lives: A prospective, observational study.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Overlap of Gastroesophageal Reflux Disease and Functional Dyspepsia and Yield of Esophagogastroduodenoscopy in Patients Clinically Fulfilling the Rome IV Criteria for Functional Dyspepsia.Frontiers in medicine · 2022Article
- Impact of Overlapping Functional Gastrointestinal Disorders on the Quality of Life in Patients With Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2021Review
- Perceived Barriers to Treatment in Persons Treated for Functional Gastrointestinal Disease with Constipation.Digestive diseases and sciences · 2021Article
- Age Cutoff and Yield of Prompt Esophagogastroduodenoscopy to Detect Malignancy in Vietnamese with Upper Gastrointestinal Symptoms: An Endoscopic Database Review of 472,744 Patients from 2014 to 2019.Canadian journal of gastroenterology & hepatology · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegulatory and treatment guidelines focus on individual conditions, yet clinicians often see patients with overlapping conditions.
objectiveThis cross-sectional survey study assesses the impact of overlapping functional dyspepsia (FD), gastroesophageal reflux disease (GERD), irritable bowel syndrome with constipation (IBS-C), and chronic idiopathic constipation (CIC) on symptom burden and consulting behavior.
methodsSurvey participants met Rome III criteria for FD, IBS-C, and/or CIC, and/or reported GERD; participants answered questions about symptom frequency and bothersomeness, work and productivity, and consulting behavior.
resultsOf 2641 respondents, 1592 (60.3%) had one condition; 832 (31.5%) had two; and 217 (8.2%) had three; 57.3% of 1690 FD, 54.6% of 1337 GERD, 82.6% of 328 IBS-C, and 62.5% of 552 CIC respondents had condition overlap. Overall GI symptoms were very/extremely bothersome in 28.6% of single-condition respondents, 50.7% of two-condition, and 69.6% of three-condition respondents (p < 0.001, chi square). Symptom frequency and productivity losses both increased with condition overlap. Over 12 months, 43.7% of single-condition, 49.9% of two-condition, and 66.5% of three-condition respondents consulted a physician about GI symptoms (p < 0.001, chi square).
conclusionFunctional GI disorders frequently overlap with each other and with GERD. Condition overlap is associated with greater symptom burden and increased physician consultations.
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