ArticleArrhythmia & electrophysiology review2016
Microvolt T-wave Alternans: Where Are We Now?
Article in Arrhythmia & electrophysiology review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- A Noise-Robust Model-Based Approach to T-Wave Amplitude Measurement and Alternans Detection.IEEE transactions on bio-medical engineering · 2026Article
- Electrocardiogram-Based Mental Stress Detection Amid Everyday Activities Using Machine Learning: Model Development and Validation Study.Journal of medical Internet research · 2026Article
- Interpretable manifold learning for T-wave alternans assessment with electrocardiographic imaging.Engineering applications of artificial intelligence · 2025Article
- Lack of Prognostic Value of T-Wave Alternans for Implantable Cardioverter-Defibrillator Benefit in Primary Prevention.Journal of the American Heart Association · 2024Article
- Tpeak-Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review.Scientifica · 2024Review
- T-Wave Analysis on the 24 h Holter ECG Monitoring as a Predictive Assessment of Major Adverse Cardiovascular Events in Patients with Myocardial Infarction: A Literature Review and Future Perspectives.Life (Basel, Switzerland) · 2023Review
- Is T-Wave Alternans a Repolarization Abnormality Marker in COVID-19? An Investigation on the Potentialities of Portable Electrocardiogram Device.Cardiology research · 2023Article
- Cardiac Alternans: From Bedside to Bench and Back.Circulation research · 2023Review
- Microvolt T-wave alternans in early repolarization syndrome associated with ventricular arrhythmias: A case report.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Article
- Dispersion of ventricular repolarization: Temporal and spatial.World journal of cardiology · 2020Review
- Effect of Hyperventilation on Periodic Repolarization Dynamics.Frontiers in physiology · 2020Article
- Current challenges in sudden cardiac death prevention.Heart failure reviews · 2020Review
- Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation.ESC heart failure · 2019Observational
- Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvolt T-wave alternans (TWA), characterised as beat-to-beat fluctuation of T-wave amplitude and morphology, is an electrophysiological phenomenon associated clinically with impending ventricular arrhythmias and is an important marker of arrhythmia risk. Currently, two main methods for the detection of TWA exist, namely, the spectral method and the time-domain modified moving average method; both are discussed in this review. Microvolt TWA has been associated with cardiovascular mortality and sudden cardiac death in several clinical studies involving >14,000 subjects with reduced as well as preserved left ventricular function. Although TWA appears to be a useful marker of susceptibility for lethal ventricular arrhythmias and cardiovascular death, so far there is no sufficient evidence from randomised clinical trials to support its use in guiding therapy. However, several ongoing trials are expected to provide more information about the clinical use of TWA testing.
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Registered trials
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