Evidence map›Paper›PMID 27403263›Full record

ArticleIranian journal of basic medical sciences2016

Alpha-tocopherol ameliorates experimental autoimmune encephalomyelitis through the regulation of Th1 cells.

Haikuo Xue, Huijun Ren, Lei Zhang, Xiaoxu Sun, Wanhai Wang, Shijie Zhang, Junwei Zhao, Liang Ming

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Antioxidant Therapy in Inflammatory Bowel Diseases.Antioxidants (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Excitotoxins, Mitochondrial and Redox Disturbances in Multiple Sclerosis.International journal of molecular sciences · 2017
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Haikuo XueDepartment of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China; Key Clinical Laboratory Medicine of Henan Province, Zhengzhou 450002, China; Department of Laboratory Medicine, Zhengzhou University, Zhengzhou, Henan 450002, China; Key Laboratory of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan450002, China.
Huijun RenDepartment of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China; Key Clinical Laboratory Medicine of Henan Province, Zhengzhou 450002, China.
Lei ZhangDepartment of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China; Department of Laboratory Medicine, Zhengzhou University, Zhengzhou, Henan 450002, China.
Xiaoxu SunDepartment of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China.
Wanhai WangKey Clinical Laboratory Medicine of Henan Province, Zhengzhou 450002, China.
Shijie ZhangKey Clinical Laboratory Medicine of Henan Province, Zhengzhou 450002, China; Key Laboratory of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan450002, China.
Junwei ZhaoDepartment of Laboratory Medicine, Zhengzhou University, Zhengzhou, Henan 450002, China.
Liang MingDepartment of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China; Key Clinical Laboratory Medicine of Henan Province, Zhengzhou 450002, China.
First Affiliated Hospital of Henan University · CNFirst Affiliated Hospital of Zhengzhou University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMultiple sclerosis (MS) is a serious neurological autoimmune disease, it commonly affects young adults. Vitamin E (Vit E) is an important component of human diet with antioxidant activity, which protects the body's biological systems. In order to assess the effect of Vit E treatment on this autoimmune disease, we established experimental autoimmune encephalomyelitis (EAE), the animal model of MS, and treated EAE with α-tocopherol (AT) which is the main content of Vit E. MATERIALS AND

methodsTwenty C57BL/6 adult female mice were used and divided into two groups randomly. EAE was induced with myelin oligodendrocyte glycoprotein (MOG), and one group was treated with AT, at a dose of 100 mg/kg on the 3(th) day post-immunization with MOG, the other group was treated with 1% alcohol. Mice were euthanized on day 14, post-immunization, spleens were removed for assessing splenocytes proliferation and cytokine profile, and spinal cords were dissected to assess the infiltration of inflammatory cells in spinal cord.

resultsAT was able to attenuate the severity of EAE and delay the disease progression. H&E staining and fast blue staining indicated that AT reduced the inflammation and the demyelination reaction in the spinal cord. Treatment with AT significantly decreased the proliferation of splenocytes. AT also inhibited the production of IFN-γ (Th1 cytokine), though the other cytokines were only affected slightly.

conclusionAccording to the results, AT ameliorated EAE, through suppressing the proliferation of T cells and the Th1 response. AT may be used as a potential treatment for MS.

Indexed as

Alpha-tocopherolAutoimmunityInflammationMultiple sclerosisVitamin E

Identifiers

PMID27403263
PMCPMC4923477
OpenAlexW2405996830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.