ArticleOman medical journal2016
Evaluation of Risk Factors for Intravenous Colistin Use-related Nephrotoxicity.
Article in Oman medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Incidence and Risk Factors of Colistin-Induced Nephrotoxicity Associated with The International Consensus Guidelines for the Optimal Use of the Polymyxins: A Retrospective Study in a Tertiary Care Hospital, Saudi Arabia.Antibiotics (Basel, Switzerland) · 2022Article
- Comparison of colistin-induced nephrotoxicity between two different formulations of colistin in critically ill patients: a retrospective cohort study.Antimicrobial resistance and infection control · 2021Article
- Insight intoInfection and drug resistance · 2018Review
- Determination of colistin-related nephrotoxicity and risk factors in intensive care unit.Northern clinics of Istanbul · 2018Article
- Serum Cystatin C for Evaluation of Acute Kidney Injury in Adults Treated with Colistin.Journal of research in pharmacy practiceArticle
- Colistin Nephrotoxicity-Age and Baseline kidney Functions Hold the Key.Indian journal of nephrologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
objectivesWe investigated the incidence of and risk factors for nephrotoxicity in patients using intravenous colistin.
methodsThis retrospective, observational study was conducted at Karadeniz Technical University, Faculty of Medicine, clinics and intensive care unit between 1 January 2009 and 1 January 2013. Intravenous colistin was administered to 133 patients at a dose of 2.5-5.0 mg/kg/day.
resultsThe patients mean age was 54.3±19.1 years and the mean duration of treatment was 13.5±3.6 days. Nephrotoxicity developed in 5.0±2.8 days in 38 (28.6%) patients. Based on RIFLE (risk, injury, failure, loss of kidney function, and end-stage kidney disease) criteria, 15 (39.5%) patients were class 1, 17 (44.7%) were class 2, six (15.8%) were class 3, and none were class 4. The mean duration of development of nephrotoxicity was 5.0±2.8 days. Hemodialysis requirement was observed in two (5.2%) of the 38 patients who developed nephrotoxicity. In these cases, colistin therapy was not discontinued. Nephrotoxicity was correlated with advanced age, high pretreatment serum creatinine levels, diabetes mellitus, and chronic obstructive pulmonary disease.
conclusionsThe use of colistin is relatively safe for patients that have normal renal functions. However, better standardization of the definition of nephrotoxicity in those patients with the use of scoring systems and close monitoring are necessary.
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