ArticleOxidative medicine and cellular longevity2016
Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Chemical Composition, Antioxidant and Antimicrobial Activities of Moroccan Equisetum ramosissimum Essential Oil and Butanolic Extract.Chemistry & biodiversity · 2026Article
- Beyond Conventional: A Review of Phytochemical-Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A Bioactive Emulgel Formulation ofGels (Basel, Switzerland) · 2025Article
- Chemical Characterization and Differential Lipid-Modulating Effects of Selected Plant Extracts from Côa Valley (Portugal) in a Cell Model for Liver Steatosis.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Structural Optimization of Cannabidiol as Multifunctional Cosmetic Raw Materials.Antioxidants (Basel, Switzerland) · 2023Article
- Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders.International journal of molecular sciences · 2022Review
- Article
- The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds.Molecules (Basel, Switzerland) · 2022Review
- Recent Advances in the Antiproliferative and Proapoptotic Activity of Various Plant Extracts and Constituents against Murine Malignant Melanoma.Molecules (Basel, Switzerland) · 2022Review
- Adipose-Derived Stem Cell-Incubated HA-Rich Sponge Matrix Implant Modulates Oxidative Stress to Enhance VEGF and TGF-Oxidative medicine and cellular longevity · 2022Article
- Phytochemistry and Pharmacology of the GenusEvidence-based complementary and alternative medicine : eCAM · 2021Review
- A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair.Oxidative medicine and cellular longevity · 2021Article
- Article
- Isokotomolide A from Cinnamomum kotoense Induce Melanoma Autophagy and ApoptosisOxidative medicine and cellular longevity · 2020Article
- A Novel Oral Astaxanthin Nanoemulsion fromOxidative medicine and cellular longevity · 2020Article
- Purified Astaxanthin fromOxidative medicine and cellular longevity · 2020Article
- Functional Analysis of Macromolecular Polysaccharides: Whitening, Moisturizing, Anti-Oxidant, and Cell Proliferation.Antioxidants (Basel, Switzerland) · 2019Article
- Inhibition of LPS-Induced Oxidative Damages and Potential Anti-Inflammatory Effects ofAntioxidants (Basel, Switzerland) · 2019Article
- Effects of a nutritional supplement in dogs affected by osteoarthritis.Veterinary medicine and science · 2019Article
- Silencing Stem Cell Factor Gene in Fibroblasts to Regulate Paracrine Factor Productions and Enhance c-Kit Expression in Melanocytes on Melanogenesis.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Equisetum ramosissimum, a genus of Equisetaceae, is a medicinal plant that can be separated into ethyl acetate (EA), dichloromethane (DM), n-hexane (Hex), methanol (MeOH), and water extracts. EA extract was known to have potent antioxidative properties, reducing power, DPPH scavenging activity, and metal ion chelating activity. This study compared these five extracts in terms of their inhibiting effects on three human malignant melanomas: A375, A375.S2, and A2058. MTT assay presented the notion that both EA and DM extracts inhibited melanoma growth but did not affect the viabilities of normal dermal keratinocytes (HaCaT) or fibroblasts. Western blot analyses showed that both EA and DM extracts induced overexpression of caspase proteins in all three melanomas. To determine their roles in melanogenesis, this study analyzed their in vitro suppressive effects on mushroom tyrosinase. All extracts except for water revealed moderate suppressive effects. None of the extracts affected B16-F10 cells proliferation. EA extract inhibited cellular melanin production whereas DM extract unexpectedly enhanced cellular pigmentation in B16-F10 cells. Data for modulations of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein 1, and tyrosinase-related protein 2 showed that EA extract inhibited protein expression mentioned above whereas DM extract had the opposite effect. Overall, the experiments indicated that the biofunctional activities of EA extract contained in food and cosmetics protect against oxidation, melanoma, and melanin production.
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