Evidence map›Paper›PMID 27403166›Full record

ArticleStem cells international2016

Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain.

Anton Pikhovych, Nina Paloma Stolberg, Lea Jessica Flitsch, Helene Luise Walter, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anton PikhovychDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany; Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.
Nina Paloma StolbergDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.
Lea Jessica FlitschDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.
Helene Luise WalterDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany; Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.
Rudolf GrafMax Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.
Gereon Rudolf FinkDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Juelich, 52425 Juelich, Germany.
Michael SchroeterDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany; Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Juelich, 52425 Juelich, Germany.
Maria Adele RuegerDepartment of Neurology, University Hospital of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany; Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Juelich, 52425 Juelich, Germany.ORCID 0000-0001-8036-395X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) has been suggested as an adjuvant tool to promote recovery of function after stroke, but the mechanisms of its action to date remain poorly understood. Moreover, studies aimed at unraveling those mechanisms have essentially been limited to the rat, where tDCS activates resident microglia as well as endogenous neural stem cells. Here we studied the effects of tDCS on microglia activation and neurogenesis in the mouse brain. Male wild-type mice were subjected to multisession tDCS of either anodal or cathodal polarity; sham-stimulated mice served as control. Activated microglia in the cerebral cortex and neuroblasts generated in the subventricular zone as the major neural stem cell niche were assessed immunohistochemically. Multisession tDCS at a sublesional charge density led to a polarity-dependent downregulation of the constitutive expression of Iba1 by microglia in the mouse cortex. In contrast, both anodal and, to an even greater extent, cathodal tDCS induced neurogenesis from the subventricular zone. Data suggest that tDCS elicits its action through multifacetted mechanisms, including immunomodulation and neurogenesis, and thus support the idea of using tDCS to induce regeneration and to promote recovery of function. Furthermore, data suggest that the effects of tDCS may be animal- and polarity-specific.

Identifiers

PMID27403166
PMCPMC4925996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.