ArticleJournal of neurointerventional surgery2017
Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort.
Article in Journal of neurointerventional surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Mechanical Thrombectomy in Nonagenarians: a Systematic Review and Meta-analysis.Translational stroke research · 2021Pooled it
- Endovascular Management of Acute Stroke in the Elderly: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Impact of age on clinical outcomes after endovascular therapy for large ischemic stroke.Journal of neurology · 2026Article
- Safety of endovascular therapy in ischemic stroke patients ⩾90 years: A cohort study from the EVA-TRISP collaboration.European stroke journal · 2026Observational
- Safety of endovascular therapy in ischemic stroke patients ⩾90 years: A cohort study from the EVA-TRISP collaboration.European stroke journal · 2025Article
- Mechanical thrombectomy in centenarians for the treatment of acute stroke: Report of 4 patients and review of the literature.Radiology case reports · 2025Article
- Mechanical Thrombectomy for Acute Ischemic Stroke in Nonagenarians: A Dilemma in Treatment Approach.Cureus · 2024Article
- Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study.Journal of neurology · 2024Observational
- Outcome of Mechanical Thrombectomy in Patients Older Than 85 Years: A Single Center Experience.Sisli Etfal Hastanesi tip bulteni · 2024Article
- Investigation of Mechanical Thrombectomy in Elderly Patients over 85 Years Old: A Multicenter Study.Neurologia medico-chirurgica · 2023Article
- Low (0-5) Alberta Stroke Program Early Computed Tomography Score on admission predictive of worse functional outcome after mechanical thrombectomy for anterior circulation large vessel occlusion.European journal of medical research · 2023Article
- Nomogram-Based Prediction of the Futile Recanalization Risk Among Acute Ischemic Stroke Patients Before and After Endovascular Therapy: A Retrospective Study.Neuropsychiatric disease and treatment · 2023Article
- Efficacy and safety of endovascular treatment in patients older than 90 with acute ischemic stroke: A retrospective cohort study.Frontiers in neurology · 2022Article
- Article
- Feasibility of Mechanical Thrombectomy for Acute Ischemic Stroke Patients Aged 90 Years or Older Compared to Younger Patients.Neurologia medico-chirurgica · 2021Article
- Outcomes of reperfusion therapy for acute ischaemic stroke in patients aged 90 years or older: a retrospective study.Internal and emergency medicine · 2021Article
- Endovascular Treatment of Very Elderly Patients Aged ≥90 With Acute Ischemic Stroke.Journal of the American Heart Association · 2020Article
- Clinical Results of Mechanical Thrombectomy in Nonagenarians with Acute Ischemic Stroke.Journal of neuroendovascular therapy · 2020Article
- Prevention and Treatment of Acute Stroke in the Nonagenarians and Beyond: Medical and Ethical Issues.Current treatment options in neurology · 2019Review
- Leukoaraiosis Attenuates Diagnostic Accuracy of Large-Vessel Occlusion Scales.AJNR. American journal of neuroradiology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRecent studies have demonstrated the superiority of endovascular therapy (EVT) for emergent large vessel occlusion.
objectiveTo determine the effectiveness of EVT in nonagenarians, for whom data are limited.
methodsWe retrospectively reviewed clinical and imaging data of all patients who underwent EVT at two stroke centers between January 2012 and August 2014. The 90-day functional outcome (modified Rankin Scale (mRS) score) was compared between younger patients (age 18-89 years; n=175) and nonagenarians (n=18). The relationship between pre-stroke and 90-day post-stroke mRS was analyzed in these two groups. Multivariable analysis of age, recanalization grade, and admission National Institutes of Health Stroke Scale (NIHSS) for predicting outcome was performed.
resultsAge ≥90 years was associated with a poor (mRS >2) 90-day outcome relative to those under 90 (89% vs 52%, OR=8, 95% CI 1.7 to 35.0; p=0.0081). Nonagenarians had a higher pre-stroke mRS score (0.77; 95% CI 0.44 to 1.30) than younger patients (0.24; 95% CI 0.17 to 0.35; p=0.005). No difference was observed between nonagenarians and younger patients in the rate of mRS change from pre-stroke to 90 days (p=0.540). On multivariable regression, age (OR=1.05, 95% CI 1.03 to 1.08; p<0.0001), recanalization grade (OR=0.62 95% CI 0.42 to 0.91; p=0.015), and admission NIHSS (OR=1.07 95% CI 1.02 to 1.13; p=0.01) were associated with a poor 90-day outcome.
conclusionsNonagenarians are at a substantially higher risk of a poor 90-day outcome after EVT than younger patients. However, a small subset of nonagenarians may benefit from EVT, particularly if they have a good pre-stroke functional status. Further research is needed to identify factors associated with favorable outcome in this age cohort.
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