ArticleProceedings of the National Academy of Sciences of the United States of America2016
Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- In tendons, differing physiological requirements lead to distinct patterns of MMP-1 degradation.Scientific reports · 2025Article
- Real-time single-molecule observation of incipient collagen fibrillogenesis and remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Alignment, cross linking, and beyond: a collagen architect's guide to the skeletal muscle extracellular matrix.American journal of physiology. Cell physiology · 2023Review
- Mechanochemistry of collagen.Acta biomaterialia · 2023Review
- The RNA landscape ofFrontiers in plant science · 2023Article
- Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling.World journal of gastroenterology · 2021Article
- The mechanics of fibrillar collagen extracellular matrix.Cell reports. Physical science · 2021Article
- Activity-dependent interdomain dynamics of matrix metalloprotease-1 on fibrin.Scientific reports · 2020Article
- Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1.Biophysical journal · 2020Article
- Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for 'use it or lose it'.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Multiscale model of fatigue of collagen gels.Biomechanics and modeling in mechanobiology · 2019Article
- Article
- Energy dissipation in mammalian collagen fibrils: Cyclic strain-induced damping, toughening, and strengthening.Acta biomaterialia · 2018Article
- Regulation of fibrosis in muscular dystrophy.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Review
- Non-enzymatic cross-linking of collagen type II fibrils is tuned via osmolality switch.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces.Biophysical journal · 2018Article
- Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides.Nature communications · 2017Article
- A New Concept of Biotensegrity Incorporating Liquid Tissues: Blood and Lymph.Journal of evidence-based integrative medicineArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Fibrillar collagen, an essential structural component of the extracellular matrix, is remarkably resistant to proteolysis, requiring specialized matrix metalloproteinases (MMPs) to initiate its remodeling. In the context of native fibrils, remodeling is poorly understood; MMPs have limited access to cleavage sites and are inhibited by tension on the fibril. Here, single-molecule recordings of fluorescently labeled MMPs reveal cleavage-vulnerable binding regions arrayed periodically at ∼1-µm intervals along collagen fibrils. Binding regions remain periodic even as they migrate on the fibril, indicating a collective process of thermally activated and self-healing defect formation. An internal strain relief model involving reversible structural rearrangements quantitatively reproduces the observed spatial patterning and fluctuations of defects and provides a mechanism for tension-dependent stabilization of fibrillar collagen. This work identifies internal-strain-driven defects that may have general and widespread regulatory functions in self-assembled biological filaments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.