ArticleArchives of disease in childhood2016
Neonatal thyroid-stimulating hormone concentration and psychomotor development at preschool age.
Article in Archives of disease in childhood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Association Between Newborn Thyroid-Stimulating-Hormone Concentration and Neurodevelopment and Growth: a Systematic Review.Biological trace element research · 2022Pooled it
- Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- Approach to Newborns with Elevated TSH: A Different Perspective from the International Guidelines for Iodine-deficient CountriesJournal of clinical research in pediatric endocrinology · 2025Review
- Usefulness of SPINA model in evaluation of the thyroid function in euthyroid pediatric patients children with subclinical hypothyroidism.Frontiers in endocrinology · 2025Article
- Impact of Lowering TSH Cut-Off on Neonatal Screening for Congenital Hypothyroidism in Minas Gerais, Brazil.International journal of neonatal screening · 2024Article
- The Role of Iodine for Thyroid Function in Lactating Women and Infants.Endocrine reviews · 2022Review
- Association of elevated neonatal thyroid-stimulating hormone levels with school performance and stimulant prescription for attention deficit hyperactivity disorder in childhood.European journal of pediatrics · 2021Article
- Investigating Prolonged Neonatal Jaundice: A Staged Approach is Superior and Conducive to Breastfeeding.Indian journal of clinical biochemistry : IJCB · 2021Article
- Comparability of thyroid-stimulating hormone immunoassays using fresh frozen human sera and external quality assessment data.PloS one · 2021Article
- Cord Blood Thyroid Hormones and Neurodevelopment in 2-Year-Old Boys and Girls.Frontiers in nutrition · 2021Article
- Neonatal thyroid-stimulating hormone and association with attention-deficit/hyperactivity disorder.Paediatric and perinatal epidemiology · 2020Article
- Review
- Developmental Screening of Children with Congenital Hypothyroidism Using Ages and Stages Questionnaires Test.Iranian journal of child neurology · 2019Article
- Newborn Screening in the US May Miss Mild Persistent Hypothyroidism.The Journal of pediatrics · 2018Article
- Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted?European journal of endocrinology · 2017Review
- Pediatric Hypothyroidism: Diagnosis and Treatment.Paediatric drugs · 2017Review
- Article
- Congenital hypothyroidism: insights into pathogenesis and treatment.International journal of pediatric endocrinology · 2017Review
- Associations between thyroid dysfunction and developmental status in children with excessive iodine status.PloS one · 2017Article
- No Association between Elevated Thyroid-Stimulating Hormone at Birth and Parent-Reported Problem Behavior at Preschool Age.Frontiers in endocrinology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThyroid hormones are essential for normal brain development. The aim of this study is to assess if high concentration of thyroid stimulating hormone (TSH) that is below the clinical threshold (5-15 mIU/L) at neonatal screening is linked to psychomotor development impairments in the offspring at preschool age.
designA total of 284 Belgian preschool children 4-6 years old and their mothers were included in the study. The children were randomly selected from the total list of neonates screened in 2008, 2009 and 2010 by the Brussels newborn screening centre. The sampling was stratified by gender and TSH range (0.45-15 mIU/L). Infants with congenital hypothyroidism (>15 mIU/L), low birth weight and/or prematurity were excluded. Psychomotor development was assessed using the Charlop-Atwell scale of motor coordination. The iodine status of children was determined using median urinary iodine concentration. Socioeconomic, parental and child potential confounding factors were measured through a self-administered questionnaire.
resultsTSH level was not significantly associated with total motor score (average change in z-score per unit increase in TSH is 0.02 (-0.03, 0.07), p=0.351), objective motor score (p=0.794) and subjective motor score (p=0.124). No significant associations were found using multivariate regression model to control confounding factors.
conclusionsMild thyroid dysfunction in the newborn-reflected by an elevation of TSH that is below the clinical threshold (5-15 mIU/L)-was not associated with impaired psychomotor development at preschool age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.