Evidence map›Paper›PMID 27402496›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Central Nervous System: (Immunological) Ivory Tower or Not?

Ioana A Marin, Jonathan Kipnis

Abstract readReview
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Rethinking stress resilience.Trends in neurosciences · 2021
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. The meningeal and choroidal infiltration routes for leukocytes in stroke.Therapeutic advances in neurological disorders · 2018
    Review
  16. Neuroimmune Activation Drives Multiple Brain States.Frontiers in systems neuroscience · 2018
    Review
  17. Article
  18. Article
  19. The Immunology of Behavior-Exploring the Role of the Immune System in Brain Health and Illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ioana A MarinCenter for Brain Immunology and Glia (BIG), Department of Neuroscience, Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Jonathan KipnisCenter for Brain Immunology and Glia (BIG), Department of Neuroscience, Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA, USA.

Funding

Meninges-to-astrocyte communication in cognitive functionR01AG034113 · NIA · UNIVERSITY OF VIRGINIA · PI KIPNIS, JONATHAN · 2010 to 2019
$3.8M
Phagocytosis of dying cells, adult neurogenesis and depressionR01MH096484 · NIMH · UNIVERSITY OF VIRGINIA · PI KIPNIS, JONATHAN, RAVICHANDRAN, KODI S · 2012 to 2016
$2.0M
NIA NIH HHS R01 AG034113NIMH NIH HHS R01 MH096484
6 · The paper itself

Abstract

The view of the nervous system being the victim of destructive inflammation during autoimmunity, degeneration, or injury has been rapidly changing. Recent studies are supporting the idea that the immune system provides support for the nervous system at various levels. Though cell patrolling through the nervous system parenchyma is limited compared with other tissues, immune cell presence within the central nervous system (CNS; microglia), as well as around it (in the meningeal spaces and choroid plexus) has been shown to be important for brain tissue maintenance and function. This review primarily explores recent findings concerning neuroimmune interactions and their mechanisms under homeostatic conditions.

Indexed as

AnimalsCentral Nervous SystemChoroid PlexusHumansImmune SystemInflammationMeningesMicroglia

Identifiers

PMID27402496
PMCPMC5143482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.