ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Role of Adiposity-Driven Inflammation in Depressive Morbidity.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Improvement in mood symptoms after post-bariatric surgery among people with obesity: A systematic review and meta-analysis.Diabetes/metabolism research and reviews · 2021Pooled it
- Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies.Frontiers in psychiatry · 2021Pooled it
- The Association of Free Fatty Acids and Eicosanoids with the Severity of Depressive Symptoms in Stroke Patients.International journal of molecular sciences · 2020Trial
- Biological motion during inflammation in humans.Brain, behavior, and immunity · 2020Trial
- Kynurenine pathway metabolites are increased in inflammatory depression and decrease with omega-3 treatment.Brain, behavior, & immunity - health · 2026Article
- Distinct Biomarker Patterns Reveal Metabolic-Inflammatory Profiles Across Mental Disorders.Biomolecules · 2026Article
- A study of mental health status and its influencing factors in normal weight obesity population.Scientific reports · 2026Article
- Adipose tissue distribution in metabolic disease: depot-specific biology, clinical assessment, and therapeutic remodeling.Frontiers in endocrinology · 2026Review
- Exercise, cognition, and affective disorders.Frontiers in sports and active living · 2026Review
- Depressive Symptoms in Obese Individuals Accompanied by Greater Basal Inflammation but Lower Monocyte Inflammatory Responses to LPS: A Quest to Uncover Immunologic Links between Depression and Obesity.Neuroimmunomodulation · 2026Article
- Atypical depression: state of the art and future perspectives.Frontiers in psychiatry · 2026Review
- Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.Frontiers in genetics · 2026Article
- Obesity and Depression: A Pathophysiotoxic Relationship.International journal of molecular sciences · 2025Review
- Parallel Pathways, Divergent Outcomes: Adipose Tissue-Neural Crosstalk in Depression and Obesity.Journal of clinical medicine · 2025Review
- Association between fat-to-muscle mass ratio and depressive symptoms in U.S. adults: evidence from a nationally representative cross-sectional study.European journal of medical research · 2025Article
- Joint Effect of Inflammatory Dietary Patterns and Physical Activity on the Risk of Depressive Symptoms: A Nation-Wide Cross-Sectional Study.Yonsei medical journal · 2025Article
- The relationship between VAI, LAP, and depression and the mediation role of sleep duration-evidence from NHANES 2005-2020.BMC psychiatry · 2025Article
- Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression.Comprehensive psychoneuroendocrinology · 2025Article
- Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice.Pharmacology · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.