Evidence map›Paper›PMID 27402234›Full record

ArticleJournal of the American Heart Association2016

Congenital Heart Disease With and Without Cyanotic Potential and the Long-term Risk of Diabetes Mellitus: A Population-Based Follow-up Study.

Nicolas L Madsen, Bradley S Marino, Jessica G Woo, Reimar W Thomsen, Jørgen Videbœk, Henning Bœkgaard Laursen, Morten Olsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Biological Age in Congenital Heart Disease-Exploring the Ticking Clock.Journal of cardiovascular development and disease · 2023
    Review
  8. Coronary artery disease in adults with congenital heart disease.International journal of cardiology. Congenital heart disease · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Observational
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  14. Article
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Nicolas L MadsenDepartment of Pediatrics, Heart Institute, University of Cincinnati College of Medicine, Cincinnati, OH nicolas.madsen@cchmc.org.
Bradley S MarinoHeart Center at the Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL Department of Pediatrics and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
Jessica G WooDepartment of Pediatrics, Heart Institute, University of Cincinnati College of Medicine, Cincinnati, OH Division of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.
Reimar W ThomsenDepartment of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
Jørgen VidebœkDepartment of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
Henning Bœkgaard LaursenDepartment of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
Morten OlsenDepartment of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
Aarhus University · DKCincinnati Children's Hospital Medical Center · USNorthwestern University · USUniversity of Cincinnati Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term survival for persons born with congenital heart disease (CHD) is improved, but limited knowledge exists of this growing population's acquired cardiovascular risk profile. This study's purpose was to assess CHD survivors' risk for type 2 diabetes mellitus (T2DM) with attention to the impact of cyanotic CHD. METHODS AND

resultsThis population-based cohort study included Danish subjects with CHD who were born between 1963 and 1980 and were alive at age 30 years. For each CHD case, we identified 10 individuals from the general population matched by sex and birth year, by using the Danish Civil Registration System. Complete follow-up was obtained through Danish public registries for death, emigration, and T2DM (diagnosis and prescriptions record). We computed cumulative incidences and hazard ratios of developing T2DM after age 30 for 5149 CHD subjects compared with the general population. After adjusting for CHD severity, as well as age, sex, preterm birth, and extracardiac defects, we analyzed the impact of cyanotic compared with acyanotic CHD. By age 45 years, the cumulative incidence of T2DM after age 30 was 4% among subjects with CHD. Subjects with CHD were more likely to develop T2DM than the general population (hazard raio 1.4, 95% CI 1.1-1.6). Subjects CHD who had cyanotic defects were more likely to develop T2DM than were subjects with acyanotic CHD (hazard ratio 1.9, 95% CI 1.1-3.3).

conclusionsCHD survivors had an increased risk of developing T2DM after age 30. Patients with cyanotic CHD are at particular risk. Given the cardiovascular health burden of T2DM, attention to its development in CHD survivors seems warranted.

Indexed as

AdultCase-Control StudiesCohort StudiesCyanosisDenmarkDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHeart Defects, CongenitalHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRisk FactorsSeverity of Illness Indexdiabetes mellitusepidemiologyheart defects (congenital)hypoxia

Identifiers

PMID27402234
PMCPMC5015361
OpenAlexW2463748386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.