ArticleJournal of the American Heart Association2016
Automated Extracellular Volume Fraction Mapping Provides Insights Into the Pathophysiology of Left Ventricular Remodeling Post-Reperfused ST-Elevation Myocardial Infarction.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Point estimate and reference normality interval of MRI-derived myocardial extracellular volume in healthy subjects: a systematic review and meta-analysis.European radiology · 2019Pooled it
- Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Trial
- Longitudinal changes and predictors of cardiac extracellular volume fraction in sickle cell anemia.Blood red cells & iron · 2025Article
- Association Between Extracellular Volume Assessed by Cardiac MRI and New-Onset Atrial Fibrillation in Patients With ST-Segment Elevation Myocardial Infarction.Korean journal of radiology · 2025Article
- Cardiac T1 mapping in non-ST-segment elevation myocardial infarction: temporal changes in myocardial fibrosis.Frontiers in cardiovascular medicine · 2025Article
- Establishment of a synthetic ECV model and its prognostic value in diabetes patients with acute myocardial infarction.Frontiers in endocrinology · 2025Article
- Contrast-enhanced cardiac MRI is superior to non-contrast mapping to predict left ventricular remodeling at 6 months after acute myocardial infarction.European radiology · 2024Article
- Acute Response in the Noninfarcted Myocardium Predicts Long-Term Major Adverse Cardiac Events After STEMI.JACC. Cardiovascular imaging · 2023Article
- Article
- Left Ventricular Adverse Remodeling in Ischemic Heart Disease: Emerging Cardiac Magnetic Resonance Imaging Biomarkers.Journal of clinical medicine · 2023Review
- Iodine-based extracellular volume for evaluating myocardial status in patients undergoing percutaneous coronary intervention for acute myocardial infarction by using dual-layer spectral detector computed tomography: a comparison study with magnetic resonance.Quantitative imaging in medicine and surgery · 2022Article
- Predictors of myocardial fibrosis and response to anti-fibrotic therapy in heart failure with preserved ejection fraction.The international journal of cardiovascular imaging · 2022Article
- Acute and Chronic Cardiopulmonary Effects of High Dose Interleukin-2 Therapy: An Observational Magnetic Resonance Imaging Study.Diagnostics (Basel, Switzerland) · 2022Article
- Relative Impact of Surgical Mitral Repair and MitraClip on Annular Remodeling-A Potential Mechanism for Therapeutic Response to Mitral Repair for Degenerative Mitral Regurgitation.Journal of cardiothoracic and vascular anesthesia · 2022Observational
- Protective effect of the Impella on the left ventricular function after acute broad anterior wall ST elevation myocardial infarctions with cardiogenic shock: cardiovascular magnetic resonance imaging strain analysis.BMC cardiovascular disorders · 2022Article
- Association of changes in the infarct and remote zone myocardial tissue with cardiac remodeling after myocardial infarction: a T1 and T2 mapping study.The international journal of cardiovascular imaging · 2022Article
- Prognostic importance of acute phase extracellular volume evaluated by cardiac magnetic resonance imaging for patients with acute myocardial infarction.The international journal of cardiovascular imaging · 2021Article
- Network model-based screen for FDA-approved drugs affecting cardiac fibrosis.CPT: pharmacometrics & systems pharmacology · 2021Article
- Circulating miR-1 as a potential predictor of left ventricular remodeling following acute ST-segment myocardial infarction using cardiac magnetic resonance.Quantitative imaging in medicine and surgery · 2020Article
- Accuracy, uncertainty, and adaptability of automatic myocardial ASL segmentation using deep CNN.Magnetic resonance in medicine · 2020Article
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Authors and funding
18 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundWhether the remote myocardium of reperfused ST-segment elevation myocardial infarction (STEMI) patients plays a part in adverse left ventricular (LV) remodeling remains unclear. We aimed to use automated extracellular volume fraction (ECV) mapping to investigate whether changes in the ECV of the remote (ECVR emote) and infarcted myocardium (ECVI nfarct) impacted LV remodeling. METHODS AND
resultsForty-eight of 50 prospectively recruited reperfused STEMI patients completed a cardiovascular magnetic resonance at 4±2 days and 40 had a follow-up scan at 5±2 months. Twenty healthy volunteers served as controls. Mean segmental values for native T1, T2, and ECV were obtained. Adverse LV remodeling was defined as ≥20% increase in LV end-diastolic volume. ECVR emote was higher on the acute scan when compared to control (27.9±2.1% vs 26.4±2.1%; P=0.01). Eight patients developed adverse LV remodeling and had higher ECVR emote acutely (29.5±1.4% vs 27.4±2.0%; P=0.01) and remained higher at follow-up (28.6±1.5% vs 26.6±2.1%; P=0.02) compared to those without. Patients with a higher ECVR emote and a lower myocardial salvage index (MSI) acutely were significantly associated with adverse LV remodeling, independent of T1Remote, T1Core and microvascular obstruction, whereas a higher ECVI nfarct was significantly associated with worse wall motion recovery.
conclusionsECVR emote was increased acutely in reperfused STEMI patients. Those with adverse LV remodeling had higher ECVR emote acutely, and this remained higher at follow-up than those without adverse LV remodeling. A higher ECVR emote and a lower MSI acutely were significantly associated with adverse LV remodeling whereas segments with higher ECVI nfarct were less likely to recover wall motion.
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