ArticleBMC complementary and alternative medicine2016
Total dosage of gardenia fruit used by patients with mesenteric phlebosclerosis.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Traditional Chinese medicine Jia Wei Gui Pi Tang improves behavioural and psychological symptoms of dementia and favourable positive emotions in patients.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2023Trial
- Extensive idiopathic mesenteric phlebosclerosis presenting as intestinal pseudo-obstruction: A case report.World journal of clinical cases · 2025Article
- A case of idiopathic mesenteric phlebosclerosis: Insight into pathogenesis of associated vascular calcification.Journal of general and family medicine · 2025Article
- Idiopathic mesenteric phlebosclerosis: a rare but important disease in Asian populations.European journal of medical research · 2025Review
- Unveiling molecular mechanisms of pigment synthesis in gardenia (Food chemistry. Molecular sciences · 2024Article
- Hangeshashinto-Associated Mesenteric Phlebosclerosis and Highly Atypical Adenoma Requiring Laparoscopic Right Hemicolectomy.Diagnostics (Basel, Switzerland) · 2024Article
- Elucidation of Geniposide and Crocin Accumulation and Their Biosysnthsis-Related Key Enzymes duringPlants (Basel, Switzerland) · 2023Article
- Widespread mesenteric phlebosclerosis presenting as intestinal obstruction due to stenosis of the right-sided colon.Clinical journal of gastroenterology · 2022Article
- Adverse Effects of Kampo Medicines.Internal medicine (Tokyo, Japan) · 2022Review
- Mesenteric phlebosclerosis associated with the oral intake of Japanese traditional (Kampo) medicines containing Gardeniae Fructus.Clinical journal of gastroenterology · 2021Article
- Idiopathic mesenteric phlebosclerosis: one case report and systematic literature review of 240 cases.American journal of translational research · 2021Article
- Mesenteric phlebosclerosis with amyloidosis in association with the long-term use of medicinal liquor: A case report.World journal of clinical cases · 2020Article
- Effects of Long-Term Administration of Gardeniae Fructus on Intra-Abdominal Organs of Rats.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula "Goshajinkigan".Journal of natural medicines · 2019Article
- Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Kihito, a Traditional Japanese Kampo Medicine, Improves Cognitive Function in Alzheimer's Disease Patients.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Recurrent Drug-induced Liver Injury Caused by the Incidental Readministration of a Kampo Formula Containing Scutellariae Radix.Internal medicine (Tokyo, Japan) · 2018Article
- Ascending colon cancer coincident with mesenteric phlebosclerosis associated with the long-term oral intake of Chinese herb containing gardenia fruit: A case report and literature review.International cancer conference journal · 2017Article
- Mesenteric Phlebosclerosis Associated with Herbal Medicine.Case reports in gastroenterologyArticle
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usage. Long-term intake of gardenia fruit (GF) is suspected as a possible cause. However, many GF users do not develop this disease and the association between GF and MP remains unclear. In this study, we investigated for the first time the dosage of GF used by patients with and without MP.
methodsWe used a medical chart review study design to assess the association between GF and MP. We reviewed patients with a history of intake of herbal medicines containing GF. Among these patients, we selected patients who were examined by colonoscopy and abdominal plain computed tomography (CT). We investigated the findings of colonoscopy, CT scan and histological examination. We assessed the total dosages of GF alongside the duration of ambulatory visit, the administration period of herbal medicine containing GF and pre-existing disease in order to compare MP cases and non-MP patients.
resultsTen MP cases and 42 non-MP patients were analyzed. We summarized clinical findings of MP cases. All MP cases used more GF than non-MP patients and were administered more than approximately 5,000 grams of GF in cumulative dosage.
conclusionsThis study indicated that excessive intake of GF contributes to and/or accelerates the development of MP suggesting that long-term usage of GF in excessive amounts increases the risk of MP.
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