ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Association Between Sleep Characteristics and Incident Dementia Accounting for Baseline Cognitive Status: A Prospective Population-Based Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Pooled it
- Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies.Journal of neurology · 2025Pooled it
- Daytime naps and depression risk: A meta-analysis of observational studies.Frontiers in psychology · 2022Pooled it
- Immune cell subsets linking insomnia trajectories and incident cognitive impairment: a prospective cohort study.BMC medicine · 2026Article
- Interactive effects of retinal biomarkers and sleep on cognition: longitudinal evidence from community-dwelling older adults.GeroScience · 2026Article
- Article
- Sleep Rhythmicity as a Core Domain of Multidimensional Sleep Health Associated with Cognitive Impairment in Older Men.Nature and science of sleep · 2026Article
- Assessment of Risk Factors for Cognitive Impairment Accounting for Genetic and Environmental Influences: An Italian Population-Based Twin Study.Brain sciences · 2025Article
- Poor sleep health is associated with older brain age: the role of systemic inflammation.EBioMedicine · 2025Article
- Individual Sleep Problems Are Associated With an Accelerated Decline in Multiple Cognitive Functions in Older Adults.Journal of sleep research · 2025Article
- Disruption of circadian rhythm as a potential pathogenesis of nocturia.Nature reviews. Urology · 2025Review
- Sleep disturbances and racial-ethnic disparities in 10-year dementia risk among a national sample of older adults in the USA.BJPsych open · 2024Article
- Association between probable sarcopenia and dementia risk: a prospective cohort study with mediation analysis.Translational psychiatry · 2024Article
- Associations between accelerometer-measured circadian rest-activity rhythm, brain structural and genetic mechanisms, and dementia.Psychiatry and clinical neurosciences · 2024Article
- The Association of the 24-Hour Activity Cycle Profiles With Cognition in Older Adults With Mild Cognitive Impairment: A Cross-Sectional Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Sleep and Caregiver Burden Among Caregivers of Persons Living With Dementia: A Scoping Review.Innovation in aging · 2024Article
- Total sleep duration and daytime napping in relation to dementia detection risk: Results from the Million Women Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Interactive association between insomnia symptoms and sleep duration for the risk of dementia-a prospective study in the Swedish National March Cohort.Age and ageing · 2023Article
- The association of night shift work with the risk of all-cause dementia and Alzheimer's disease: a longitudinal study of 245,570 UK Biobank participants.Journal of neurology · 2023Article
- Circadian rest-activity rhythm and longitudinal brain changes underlying late-life cognitive decline.Psychiatry and clinical neurosciences · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough research has shown that sleep disorders are prevalent among people with dementia, the temporal relationship is unclear. We investigated whether atypical sleep characteristics were associated with incident dementia while accounting for baseline cognitive functioning.
methodsScreening Across the Lifespan Twin (SALT) study participants were 11,247 individuals from the Swedish Twin Registry who were at least 65 years at baseline (1998-2002). Sleep and baseline cognitive functioning were assessed via the SALT telephone screening interview. Data on dementia diagnoses came from national health registers. Cox regression was performed to estimate hazard ratios for dementia.
resultsAfter 17 years of follow-up, 1,850 dementia cases were identified. Short (≤6 hours) and extended (>9 hours) time in bed (TIB) compared to the middle reference group (hazard ratio = 1.40, 95% confidence interval = 1.06-1.85; hazard ratio = 1.11, 95% confidence interval = 1.00-1.24, respectively) and rising at 8:00 AM or later compared to earlier rising (hazard ratio = 1.12, 95% confidence interval = 1.01-1.24) were associated with higher dementia incidence. Bedtime, sleep quality, restorative sleep, and heavy snoring were not significant predictors. Findings stratified by baseline cognitive status indicated that the association between short TIB and dementia remained in those cognitively intact at the start.
conclusionsShort and extended TIB and delayed rising among older adults predicted increased dementia incidence in the following 17 years. The pattern of findings suggests that extended TIB and late rising represent prodromal features whereas short TIB appeared to be a risk factor for dementia.
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