Evidence map›Paper›PMID 27401740›Full record

ArticleHeart and vessels2017

Assessment of vascular autonomic function using peripheral arterial tonometry.

Satomi Hamada, Ai Oono, Yuri Ishihara, Yuki Hasegawa, Miho Akaza, Yuki Sumi, Yoshinori Inoue, Hajime Izumiyama, Kenzo Hirao, Mitsuaki Isobe and 1 more

Abstract read
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In one paragraph

Article in Heart and vessels, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Satomi HamadaDepartment of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan.
Ai OonoDepartment of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan.
Yuri IshiharaDepartment of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan.
Yuki HasegawaDepartment of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan.
Miho AkazaDepartment of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan.
Yuki SumiDepartment of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan.
Yoshinori InoueDepartment of Vascular and Applied Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Hajime IzumiyamaDepartment of Molecular Endocrinology and Metabolism, and Center for Medical Welfare and Liaison Services, Tokyo Medical and Dental University, Tokyo, Japan.
Kenzo HiraoHeart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan.
Mitsuaki IsobeDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tetsuo SasanoDepartment of Biofunctional Informatics, Tokyo Medical and Dental University School of Health Care Sciences, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan. sasano.bi@tmd.ac.jp.ORCID http://orcid.org/0000-0003-3582-6104
Tokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral autonomic function is impaired in diabetic polyneuropathy. However, it is difficult to evaluate it due to the lack of non-invasive quantitative assessment. We aimed to establish a novel index to evaluate vascular autonomic function using reactive hyperemia peripheral arterial tonometry (RH-PAT), a widely performed endothelial function test. Sixty-five subjects were enrolled, including healthy subjects, cases with sympathetic nerve blockers, and diabetic patients. RH-PAT was performed with 5-min blood flow occlusion in unilateral arm. We calculated the reduction ratio of the post-occlusion pulse amplitude to the baseline in the non-occluded arm (RPN), with 1-min sliding window. In healthy subjects, RPN gradually increased with time-dependent manner. However, this phenomenon was eliminated in cases with sympathetic nerve blockers. Plasma concentration of norepinephrine was measured before and after the blood flow occlusion, which showed a significant increase. We then compared RPNs with the change in heart rate variability (HRV) parameters. RPN calculated at 5 min after the reperfusion had the highest correlation with the change in sympathetic HRV parameter, and thus, we named sympathetic hypoemia index (SHI). Finally, we studied the relationship between SHI and diabetes. SHI was significantly lower in diabetic patients than matched controls. SHI, a novel index derived from RH-PAT, represented the peripheral sympathetic activity. SHI may be useful for assessing the vascular autonomic activity in diabetic patients.

Indexed as

AgedAged, 80 and overCardiovascular Physiological PhenomenaCase-Control StudiesDiabetic NeuropathiesEndothelium, VascularFemaleHumansHyperemiaJapanMaleManometryMiddle AgedNorepinephrineRegression AnalysisSympathetic Nervous SystemNorepinephrineDiabetic polyneuropathyEndothelial functionPeripheral arterial tonometrySympathetic activitySympathetic hypoemia index

Identifiers

PMID27401740
OpenAlexW2466282344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.