Evidence map›Paper›PMID 27401738›Full record

ArticleHeart and vessels2017

Prominent QTc prolongation in a patient with a rare variant in the cardiac ryanodine receptor gene.

Yuki Taniguchi, Aya Miyazaki, Heima Sakaguchi, Yousuke Hayama, Norihiro Ebishima, Jun Negishi, Kanae Noritake, Yoshihiro Miyamoto, Wataru Shimizu, Takeshi Aiba and 1 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. RYR2-ryanodinopathies: from calcium overload to calcium deficiency.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yuki TaniguchiDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Aya MiyazakiDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan. ayamiya@ncvc.go.jp.
Heima SakaguchiDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Yousuke HayamaDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Norihiro EbishimaDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Jun NegishiDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Kanae NoritakeDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Yoshihiro MiyamotoDepartment of Preventive Cardiology, Department of Medicine and Epidemiologic Informatics, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Wataru ShimizuDepartment of Cardiovascular Medicine, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Takeshi AibaDepartment of Cardiovascular Medicine, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
Hideo OhuchiDepartment of Pediatric Cardiology, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan.
National Cerebral and Cardiovascular Center · JPNippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a 12-year-old female patient with a history of four syncopal episodes related to exercise over 2 years and who showed prominent QTc prolongation on electrocardiogram; therefore, she was clinically diagnosed with long QT syndrome type-1. However, genetic analysis did not identify any LQT-related genes but showed a rare missense variant in the cardiac ryanodine receptor gene. From the results of drug-loading tests, administration of oral propranolol was initiated; thereafter, she experienced no syncopal episodes. This is a case report demonstrating the "overlapping clinical features" of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia.

Indexed as

ChildElectrocardiographyFemaleGenetic TestingHumansLong QT SyndromeMutation, MissensePolymorphic Catecholaminergic Ventricular TachycardiaRyanodine Receptor Calcium Release ChannelSyncopeTachycardia, VentricularRyanodine Receptor Calcium Release ChannelCatecholaminergic polymorphic ventricular tachycardiaLong QT syndromePremature ventricular conductionRyanodine receptor 2 gene

Identifiers

PMID27401738
OpenAlexW2462826992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.