ReviewJournal of the American Society of Nephrology : JASN2016
Pragmatic Trials in Maintenance Dialysis: Perspectives from the Kidney Health Initiative.
Review in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- The TiME Trial: A Fully Embedded, Cluster-Randomized, Pragmatic Trial of Hemodialysis Session Duration.Journal of the American Society of Nephrology : JASN · 2019Trial
- Phased Introduction of Haemodialysis in Patients with Kidney Failure: A Mixed-Methods Feasibility Study.Healthcare (Basel, Switzerland) · 2026Article
- Updates in the management of intradialytic hypotension: Emerging strategies and innovations.World journal of nephrology · 2025Review
- A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol.Clinical and experimental nephrology · 2021Article
- Design and Rationale of HiLo: A Pragmatic, Randomized Trial of Phosphate Management for Patients Receiving Maintenance Hemodialysis.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
- Patient Partner Perspectives Regarding Ethically and Clinically Important Aspects of Trial Design in Pragmatic Cluster Randomized Trials for Hemodialysis.Canadian journal of kidney health and disease · 2021Article
- The current and future landscape of dialysis.Nature reviews. Nephrology · 2020Review
- Kidney disease trials for the 21st century: innovations in design and conduct.Nature reviews. Nephrology · 2020Review
- Ethical Issues in the Design and Conduct of Pragmatic Cluster Randomized Trials in Hemodialysis Care: An Interview Study With Key Stakeholders.Canadian journal of kidney health and disease · 2020Article
- Ethical Issues in Pragmatic Cluster-Randomized Trials in Dialysis Facilities.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Review
- Addressing guideline and policy changes during pragmatic clinical trials.Clinical trials (London, England) · 2019Article
- Pragmatic clinical trials offer unique opportunities for disseminating, implementing, and sustaining evidence-based practices into clinical care: Proceedings of a workshop.Healthcare (Amsterdam, Netherlands) · 2019Review
- A Pragmatic Step Forward: AKI and Beyond.Journal of the American Society of Nephrology : JASN · 2019Article
- Cultivating Innovative Pragmatic Cluster-Randomized Registry Trials Embedded in Hemodialysis Care: Workshop Proceedings From 2018.Canadian journal of kidney health and disease · 2019Article
- Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol.BMC medical ethics · 2018Article
- Perspectives on Research Participation and Facilitation Among Dialysis Patients, Clinic Personnel, and Medical Providers: A Focus Group Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Article
- Article
- Research Priorities for Palliative Care for Older Adults with Advanced Chronic Kidney Disease.Journal of palliative medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
Pragmatic clinical trials are conducted under the real-world conditions of clinical care delivery. As a result, these trials yield findings that are highly generalizable to the nonresearch setting, identify interventions that are readily translatable into clinical practice, and cost less than trials that require extensive research infrastructures. Maintenance dialysis is a setting especially well suited for pragmatic trials because of inherently frequent and predictable patient encounters, highly granular and uniform data collection, use of electronic data systems, and delivery of care by a small number of provider organizations to approximately 90% of patients nationally. Recognizing the potential for pragmatic trials to generate much needed evidence to guide the care of patients receiving maintenance dialysis, the Kidney Health Initiative assembled a group of individuals with relevant expertise from academia, industry, and government to provide the nephrology community with information about the design and conduct of such trials, with a specific focus on the dialysis setting. Here, we review this information, and where applicable, use experience from the ongoing Time to Reduce Mortality in End Stage Renal Disease Trial, a large cluster-randomized, pragmatic trial evaluating hemodialysis session duration, to illustrate challenges and solutions to operational, ethical, and regulatory issues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.