Evidence map›Paper›PMID 27401475›Full record

Trial reportBMC medical informatics and decision making2016

The effect of an interactive weekly mobile phone messaging on retention in prevention of mother to child transmission (PMTCT) of HIV program: study protocol for a randomized controlled trial (WELTEL PMTCT).

Patricia Opondo Awiti, Alessandra Grotta, Mia van der Kop, John Dusabe, Anna Thorson, Jonathan Mwangi, Rino Belloco, Richard Lester, Laura Ternent, Edwin Were and 1 more

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in BMC medical informatics and decision making, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patricia Opondo AwitiDepartment of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden. Patricia.Awiti@ki.se.
Alessandra GrottaDepartment of Medical Epidemiology and Statistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Mia van der KopDivision of Infectious diseases, University of British Columbia, Vancouver, Canada.
John DusabeDepartment of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden.
Anna ThorsonDepartment of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden.
Jonathan MwangiDepartment of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden.
Rino BellocoDepartment of Medical Epidemiology and Statistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Richard LesterDepartment of Medicine, University of British Columbia, Vancouver, Canada.
Laura TernentNewcastle University, Tyne and Wear, NE1 7RU, UK.
Edwin WereDepartment of Reproductive Health, Moi University, P.O.BOX 3900-30100, Eldoret, Kenya.
Anna Mia EkströmDepartment of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImproving retention in prevention of mother to child transmission (PMTCT) of HIV programs is critical to optimize maternal and infant health outcomes, especially now that lifelong treatment is immediate regardless of CD4 cell count). The WelTel strategy of using weekly short message service (SMS) to engage patients in care in Kenya, where mobile coverage even in poor areas is widespread has been shown to improve adherence to antiretroviral therapy (ART) and viral load suppression among those on ART. The aim of this study is to determine the effect of the WelTel SMS intervention compared to standard care on retention in PMTCT program in Kenya.

methodsWelTel PMTCT is a four to seven-centers, two-arm open randomized controlled trial (RCT) that will be conducted in urban and rural Kenya. Over 36 months, we plan to recruit 600 pregnant women at their first antenatal care visit and follow the mother-infant pair until they are discharged from the PMTCT program (when infant is aged 24 months). Participants will be randomly allocated to the intervention or control arm (standard care) at a 1:1 ratio. Intervention arm participants will receive an interactive weekly SMS 'How are you?' to which they are supposed to respond within 24 h. Depending on the response (ok, problem or no answer), a PMTCT nurse will follow-up and triage any problems that are identified. The primary outcome will be retention in care defined as the proportion of mother-infant pairs coming for infant HIV testing at 24 months from delivery. Secondary outcomes include a) adherence to WelTel; (b) adherence to antiretroviral medicine; (c) acceptance of WelTel and (d) cost-effectiveness of the WelTel intervention. DISCUSSION: This trial will provide evidence on the effectiveness of mHealth for PMTCT retention. Trial results and the cost-effectiveness evaluation will be used to inform policy and potential scale-up of mHealth among mothers living with HIV.

trial registrationISRCTN98818734 ; registered on 9th December 2014.

Indexed as

Medication AdherenceText MessagingAdolescentAdultAnti-Retroviral AgentsFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalKenyaTelemedicineYoung AdultAnti-Retroviral AgentsAntiretroviral therapy (ART)HIV/PMTCTKenyaMobile health (m-health)Retention

Identifiers

PMID27401475
PMCPMC4940723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.