Evidence map›Paper›PMID 27401256›Full record

ArticleNeurochemical research2017

Uncoupling Protein 2 (UCP2) Function in the Brain as Revealed by the Cerebral Metabolism of (1-

Laura Contreras, Eduardo Rial, Sebastian Cerdan, Jorgina Satrustegui

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Laura ContrerasDepartamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, CSIC-UAM-Universidad Autónoma de Madrid, c/Nicolás Cabrera 1, 28049, Madrid, Spain.
Eduardo RialDepartamento de Medicina Celular y Molecular, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040, Madrid, Spain.
Sebastian CerdanLaboratory for Imaging and Spectroscopy by Magnetic Resonance (LISMAR), Instituto de Investigaciones Biomédicas 'Alberto Sols' C.S.I.C./U.A.M., c/ Arturo Duperier 4, 28029, Madrid, Spain. scerdan@iib.uam.es.
Jorgina SatrusteguiDepartamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, CSIC-UAM-Universidad Autónoma de Madrid, c/Nicolás Cabrera 1, 28049, Madrid, Spain. jsatrustegui@cbm.csic.es.
Consejo Superior de Investigaciones Científicas · ESInstituto de Investigación de Enfermedades Raras · ESInstituto de Investigaciones Biomédicas Sols-Morreale · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mitochondrial aspartate/glutamate transporter Aralar/AGC1/Slc25a12 is critically involved in brain aspartate synthesis, and AGC1 deficiency results in a drastic fall of brain aspartate levels in humans and mice. It has recently been described that the uncoupling protein UCP2 transports four carbon metabolites including aspartate. Since UCP2 is expressed in several brain cell types and AGC1 is mainly neuronal, we set to test whether UCP2 could be a mitochondrial aspartate carrier in the brain glial compartment. The study of the cerebral metabolism of (1-

Indexed as

AnimalsCarbon IsotopesCerebral Cortexgamma-Aminobutyric AcidGlucoseGlutamic AcidGlutamineMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutUncoupling Protein 2Carbon Isotopesgamma-Aminobutyric AcidGlucoseGlutamic AcidGlutamineUcp2 protein, mouseUncoupling Protein 2(1–13C)-glucoseAspartateCerebral metabolismMitochondriaUCP2

Identifiers

PMID27401256
OpenAlexW2462217509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.