ArticleGenome biology and evolution2016
The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts.iScience · 2024Article
- Genomic Signatures Associated with Transitions to Viviparity in Cyprinodontiformes.Molecular biology and evolution · 2023Article
- Comparative analysis reveals epigenomic evolution related to species traits and genomic imprinting in mammals.Innovation (Cambridge (Mass.)) · 2023Article
- A burst of genomic innovation at the origin of placental mammals mediated embryo implantation.Communications biology · 2023Article
- MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function.iScience · 2023Article
- Decidual cells and decidualization in the carnivoran endotheliochorial placenta.Frontiers in cell and developmental biology · 2023Review
- Transposable Elements Continuously Remodel the Regulatory Landscape, Transcriptome, and Function of Decidual Stromal Cells.Genome biology and evolution · 2022Article
- Genome biology of the darkedged splitfin,Genome research · 2022Article
- Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: a minimal ancestral deciduogenic signal†.Biology of reproduction · 2022Article
- Article
- Unique Aspects of Human Placentation.International journal of molecular sciences · 2021Review
- Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals.Molecular biology and evolution · 2021Article
- Developing a theoretical evolutionary framework to solve the mystery of parturition initiation.eLife · 2020Review
- Comparative transcriptomics of primary cells in vertebrates.Genome research · 2020Article
- Endometrial Decidualization: The Primary Driver of Pregnancy Health.International journal of molecular sciences · 2020Review
- Stress-Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Resveratrol inhibits decidualization by accelerating downregulation of the CRABP2-RAR pathway in differentiating human endometrial stromal cells.Cell death & disease · 2019Article
- The mammalian decidual cell evolved from a cellular stress response.PLoS biology · 2018Article
- Effects of forkhead box protein M1 on trophoblast invasion and its role in preeclampsia development.Experimental and therapeutic medicine · 2018Article
- Pervasive Correlated Evolution in Gene Expression Shapes Cell and Tissue Type Transcriptomes.Genome biology and evolution · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endometrial stromal fibroblast (ESF) is a cell type present in the uterine lining of therian mammals. In the stem lineage of eutherian mammals, ESF acquired the ability to differentiate into decidual cells in order to allow embryo implantation. We call the latter cell type "neo-ESF" in contrast to "paleo-ESF" which is homologous to eutherian ESF but is not able to decidualize. In this study, we compare the transcriptomes of ESF from six therian species: Opossum (Monodelphis domestica; paleo-ESF), mink, rat, rabbit, human (all neo-ESF), and cow (secondarily nondecidualizing neo-ESF). We find evidence for strong stabilizing selection on transcriptome composition suggesting that the expression of approximately 5,600 genes is maintained by natural selection. The evolution of neo-ESF from paleo-ESF involved the following gene expression changes: Loss of expression of genes related to inflammation and immune response, lower expression of genes opposing tissue invasion, increased markers for proliferation as well as the recruitment of FOXM1, a key gene transiently expressed during decidualization. Signaling pathways also evolve rapidly and continue to evolve within eutherian lineages. In the bovine lineage, where invasiveness and decidualization were secondarily lost, we see a re-expression of genes found in opossum, most prominently WISP2, and a loss of gene expression related to angiogenesis. The data from this and previous studies support a scenario, where the proinflammatory paleo-ESF was reprogrammed to express anti-inflammatory genes in response to the inflammatory stimulus coming from the implanting conceptus and thus paving the way for extended, trans-cyclic gestation.
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