ArticleCell stress & chaperones2016
Utility of 17-(allylamino)-17-demethoxygeldanamycin treatment for skeletal muscle injury.
Article in Cell stress & chaperones, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- LNC_003296 regulates the proliferation and differentiation of ovine myoblasts by modulating the stability of Hsp70.The veterinary quarterly · 2026Article
- CORP: In vivo muscle strength-perspectives on the design and interpretation of preclinical animal studies.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Review
- Traumatic Skeletal Muscle Injury and Recovery.Advances in experimental medicine and biology · 2025Review
- Cardiac and skeletal muscle manifestations in the G608G mouse model of Hutchinson-Gilford progeria syndrome.Aging cell · 2024Article
- Adaptability to eccentric exercise training is diminished with age in female mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Mechanisms of weakness in Mdx muscle following in vivo eccentric contractions.Journal of muscle research and cell motility · 2022Article
- Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function FollowingFrontiers in rehabilitation sciences · 2021Article
- Plasmalemma Function Is Rapidly Restored in Mdx Muscle after Eccentric Contractions.Medicine and science in sports and exercise · 2020Article
- Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice.JCI insight · 2019Article
- Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration.Molecular and cellular biology · 2018Article
- Downhill exercise alters immunoproteasome content in mouse skeletal muscle.Cell stress & chaperones · 2018Article
- BGP-15 improves contractile function of regenerating soleus muscle.Journal of muscle research and cell motility · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Repeated eccentric contractions can injure skeletal muscle and result in functional deficits that take several weeks to fully recover. The 70-kDa heat shock protein (Hsp70) is a stress-inducible molecular chaperone that maintains protein quality and plays an integral role in the muscle's repair processes following injury. Here, we attempted to hasten this recovery by pharmacologically inducing Hsp70 expression in mouse skeletal muscle with 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) (40 mg/kg) both prior to and throughout the first 7 days after an injurious bout of 150 maximal eccentric contractions. Hsp70 content in the injured skeletal muscle was strongly induced following the eccentric contractions and remained elevated over the next 7 days as the muscle underwent repair. Treatment with 17-AAG increased Hsp70 content ∼fivefold; however, this was significantly less than that induced by the injury. Moreover, 17-AAG treatment did not recover the decrements to in vivo isometric torque production following the bout of eccentric contractions. Together, these findings demonstrate that although Hsp70 content was induced in the uninjured skeletal muscle, treatment of 17-AAG (40 mg/kg) was not a preventive measure to either reduce the severity of skeletal muscle damage or enhance functional recovery following a bout of maximal eccentric contractions.
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