SynthesisBMC medicine2016
The role of peptides in bone healing and regeneration: a systematic review.
Synthesis in BMC medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed.
- Article
- A Layered Framework for Biological Aesthetics: A Narrative Review of Regenerative Medicine in Cosmetic Science.Cureus · 2026Review
- Analysis of Dissolution, Pharmacokinetic, and Bone-Protective Differences Among Calcium Formulations with Different Dosage Forms and Calcium Sources.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies.Bone research · 2026Review
- Mechanism-Guided Nanoengineered Therapeutic Peptides for Bone Healing.International journal of nanomedicine · 2026Review
- Self-assembling peptide nanofibers as growth factor-mimicking scaffolds enhancing the bone regeneration potential of nanoceramics: a triad ofRSC advances · 2025Article
- A Paired Database of Predicted and Experimental Protein Peptide Binding Information.Scientific data · 2025Article
- The Impact of Red Blood Cell Count and Hemoglobin Levels on Bone Remodeling in Mandibular Angle Osteotomy.Aesthetic plastic surgery · 2025Article
- Analysis of the Effect of Human Type I Collagen-Derived Peptide on Bone Regenerative Capacity and Comparison with Various Collagen Materials In Vivo.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring indigenous knowledge and practices of the Gurage community on the biosystematics and utilization of Enset landraces for bone fracture and regeneration: the case of Gurage Zone, central Ethiopia region.Frontiers in pharmacology · 2025Article
- Chitosan-Peptide Composites for Tissue Engineering Applications: Advances in Treatment Strategies.Current protein & peptide science · 2025Review
- The Future of Bone Repair: Emerging Technologies and Biomaterials in Bone Regeneration.International journal of molecular sciences · 2024Review
- Green Synthesis of Silver Nanoparticles with Roasted Green Tea: Applications in Alginate-Gelatin Hydrogels for Bone Regeneration.Gels (Basel, Switzerland) · 2024Article
- Review
- Hybrid Hydroxyapatite-Metal Complex Materials Derived from Amino Acids and Nucleobases.Molecules (Basel, Switzerland) · 2024Review
- Presenting dual-functional peptides on implant surface to direct in vitro osteogenesis and in vivo osteointegration.Materials today. Bio · 2024Article
- Activation of CGRP receptor-mediated signaling promotes tendon-bone healing.Science advances · 2024Article
- Peptide-Based Biomaterials for Bone and Cartilage Regeneration.Biomedicines · 2024Review
- Evaluation of osteoconductive effect of polycaprolactone (PCL) scaffold treated withAmerican journal of stem cells · 2024Article
- A pre-market interventional, single-arm clinical investigation of a new topical lotion based on hyaluronic acid and peptides, EGYFILBMC musculoskeletal disorders · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration.
methodsA systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.
resultsBased on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited.
conclusionFurther research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge.
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