Evidence map›Paper›PMID 27400929›Full record

ArticleJournal of neurovirology2016

β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization.

Seth M Dever, Myosotys Rodriguez, Nazira El-Hage

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Cerebrospinal Fluid Norepinephrine and Neurocognition in HIV and Methamphetamine Dependence.Journal of acquired immune deficiency syndromes (1999) · 2020
    Article
  3. Review
  4. Alternative splicing isoforms in health and disease.Pflugers Archiv : European journal of physiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Seth M DeverDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Myosotys RodriguezDepartment of Immunology, Florida International University Herbert Wertheim College of Medicine, 11200 SW 8th Street, Miami, FL, 33199, USA.
Nazira El-HageDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. nelhage@fiu.edu.
Florida International University · USVirginia Commonwealth University · US

Funding

The Manahattan HIV Brain BankR24MH059724 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MORGELLO, SUSAN · 1998 to 2007
$15.4M
NEUROAIDS TISSUE NETWORKR24MH059745 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 1998 to 2007
$13.2M
NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
National Neurological AIDS Bank (NNAB)R24NS038841 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 1998 to 2007
$12.0M
The Manhattan HIV Brain BankU01MH083501 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2008 to 2012
$8.9M
California NeuroAIDS Tissue Network (CNTN)U01MH083506 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2008 to 2012
$8.1M
TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCHR24NS045491 · NINDS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI GELMAN, BENJAMIN B. · 2002 to 2007
$8.1M
National Neurological AIDS BankU01MH083500 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2008 to 2012
$7.2M
Texas Repository for AIDS Neuropathogenesis ResearchU01MH083507 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GELMAN, BENJAMIN B. · 2008 to 2012
$5.1M
National NeuroAIDS Tissue Consortium Statistics and Data Coordinating CenterU01MH083545 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI YIANNOUTSOS, CONSTANTIN THEODORE · 2008 to 2012
$3.3M
Role of Autophagy in Microglia-induced NeuroAIDS in Substance AbuseR01DA036154 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI EL-HAGE, NAZIRA · 2013 to 2017
$1.9M
Impact of μ-opioid receptor (MOR) splice variant interactions with the chemokine receptor CCR5 in the context of morphine and HIV-1 entry inhibitor therapyR21DA041287 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI EL-HAGE, NAZIRA · 2016 to 2017
$363k
NIDA NIH HHS F32 DA033898NIDA NIH HHS R01 DA036154NIDA NIH HHS R21 DA041287NIMH NIH HHS N01 MH032002NIMH NIH HHS R24 MH059724NIMH NIH HHS R24 MH059745NIMH NIH HHS U01 MH083500NIMH NIH HHS U01 MH083501NIMH NIH HHS U01 MH083506NIMH NIH HHS U01 MH083507NIMH NIH HHS U01 MH083545NIMH NIH HHS U24 MH100929NINDS NIH HHS R24 NS038841NINDS NIH HHS R24 NS045491
6 · The paper itself

Abstract

We previously reported that mRNA expression of the unique alternatively spliced OPRM1 isoform μ-opioid receptor-1K (MOR-1K), which exhibits excitatory cellular signaling, is elevated in HIV-infected individuals with combined neurocognitive impairment (NCI) and HIV encephalitis (HIVE). It has recently been shown that the β

Indexed as

AIDS Dementia ComplexAstrocytesEncephalitis, ViralFrontal LobeGene Expression RegulationHumansMorphinePrimary Cell CultureProtein IsoformsReceptors, Adrenergic, beta-2Receptors, Opioid, muRNA, MessengerWhite MatterADRB2 protein, humanMorphineOPRM1 protein, humanProtein IsoformsReceptors, Adrenergic, beta-2Receptors, Opioid, muRNA, MessengerCentral nervous systemHIV-associated neurocognitive disordersHIV encephalitisSplice variantβ-Adrenergic receptorμ-Opioid receptor

Identifiers

PMID27400929
PMCPMC5228594
OpenAlexW2460968140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.