Evidence map›Paper›PMID 27400857›Full record

ArticleMolecular psychiatry2017

Lithium suppression of tau induces brain iron accumulation and neurodegeneration.

P Lei, S Ayton, A T Appukuttan, S Moon, J A Duce, I Volitakis, R Cherny, S J Wood, M Greenough, G Berger and 5 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
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  8. In defence of ferroptosis.Signal transduction and targeted therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 4 countries.

P LeiDepartment of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Sichuan, China.ORCID 0000-0001-5652-1962
S AytonFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
A T AppukuttanFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
S MoonFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
J A DuceFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
I VolitakisFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
R ChernyFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
S J WoodMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, VIC, Australia.
M GreenoughFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
G BergerORYGEN Research Centre, University of Melbourne and Melbourne Health, Parkville, VIC, Australia.
C PantelisFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0002-9565-0238
P McGorryORYGEN Research Centre, University of Melbourne and Melbourne Health, Parkville, VIC, Australia.
A YungInstitute of Brain, Behaviour and Mental Health, University of Manchester and Greater Manchester West NHS Mental Health Trust, Manchester, UK.
D I FinkelsteinFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
A I BushFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
The University of Melbourne · AUGreater Manchester Mental Health NHS Foundation Trust · GBUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand tremor, often limit its use. The understanding of the neurobiological basis of these side effects is still very limited. Nigral iron elevation is also a feature of Parkinsonian degeneration that may be related to soluble tau reduction. We found that magnetic resonance imaging T

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainHumansIronLithiumMaleMiceMice, KnockoutNeuronsParkinsonian Disorderstau ProteinsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorIronLithiumtau Proteins

Identifiers

PMID27400857
OpenAlexW2465435205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.