ArticleHuman brain mapping2016
Preserved white matter microstructure in young patients with anorexia nervosa?
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- White Matter Abnormalities in Anorexia Nervosa: Psychoradiologic Evidence From Meta-Analysis of Diffusion Tensor Imaging Studies Using Tract Based Spatial Statistics.Frontiers in neuroscience · 2020Pooled it
- Altered thalamo–cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studiesJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Dynamic white matter microstructure in anorexia nervosa: associations with neurofilament light and leptin across early weight restoration.Research square · 2026Article
- Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.Molecular psychiatry · 2025Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.medRxiv : the preprint server for health sciences · 2024Article
- Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study.Scientific reports · 2022Article
- White matter microstructural differences in underweight adolescents with anorexia nervosa and a preliminary longitudinal investigation of change following short-term weight restoration.Eating and weight disorders : EWD · 2021Article
- Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review.Children (Basel, Switzerland) · 2021Review
- The Neurobiology of Eating Disorders.Child and adolescent psychiatric clinics of North America · 2019Review
- Preserved white matter microstructure in adolescent patients with atypical anorexia nervosa.The International journal of eating disorders · 2019Article
- White Matter Abnormalities in the Corpus Callosum in Acute and Recovered Anorexia Nervosa Patients-A Diffusion Tensor Imaging Study.Frontiers in psychiatry · 2019Article
- Sex Differences in White Matter Pathways Related to Language Ability.Frontiers in neuroscience · 2019Article
- An Overview of Conceptualizations of Eating Disorder Recovery, Recent Findings, and Future Directions.Current psychiatry reports · 2018Review
- Structural Neuroimaging of Anorexia Nervosa: Future Directions in the Quest for Mechanisms Underlying Dynamic Alterations.Biological psychiatry · 2018Review
- Neural correlates of altered feedback learning in women recovered from anorexia nervosa.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A massive but reversible reduction of cortical thickness and subcortical gray matter (GM) volumes in Anorexia Nervosa (AN) has been recently reported. However, the literature on alterations in white matter (WM) volume and microstructure changes in both acutely underweight AN (acAN) and after recovery (recAN) is sparse and results are inconclusive. Here, T1-weighted and diffusion-weighted MRI data in a sizable sample of young and medication-free acAN (n = 35), recAN (n = 32), and age-matched female healthy controls (HC, n = 62) were obtained. For analysis, a well-validated global probabilistic tractography reconstruction algorithm including rigorous motion correction implemented in FreeSurfer: TRACULA (TRActs Constrained by UnderLying Anatomy) were used. Additionally, a clustering algorithm and a multivariate pattern classification technique to WM metrics to predict group membership were applied. No group differences in either WM volume or WM microstructure were detected with standard analysis procedures either in acAN or recAN relative to HC after controlling for the number of performed statistical tests. These findings were not affected by age, IQ, or psychiatric symptoms. While cluster analysis was unsuccessful at discriminating between groups, multivariate pattern classification showed some ability to separate acAN from HC (but not recAN from HC). However, these results were not compatible with a straightforward hypothesis of impaired WM microstructure. The current findings suggest that WM integrity is largely preserved in non-chronic AN. This finding stands in contrast to findings in GM, but may help to explain the relatively intact cognitive performance of young patients with AN and provide the basis for the fast recovery of GM structures. Hum Brain Mapp 37:4069-4083, 2016. © 2016 Wiley Periodicals, Inc.
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