ArticleJournal of translational medicine2016
Characterisation and comparison of adipose tissue macrophages from human subcutaneous, visceral and perivascular adipose tissue.
Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 77 citations in OpenAlex.
- The prognostic role of preoperative subcutaneous adipose tissue measurement in lung transplantation.BMC pulmonary medicine · 2026Article
- Oxidative Stress in Diabetic Cardiomyopathy: Molecular Mechanisms and Emerging Therapeutic Targets.Biomolecules · 2026Review
- A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment.Advanced healthcare materials · 2026Article
- Integrated metabolomic and transcriptomic profiling reveals lipid dysregulation and potential biomarkers in interstitial lung disease.Frontiers in immunology · 2026Article
- Lipidomics of polarized macrophages in the human adipose tissue.Scientific reports · 2025Article
- Phenotypic Shifts in Macrophages Within Advanced Atherosclerotic Plaques in Humans.FASEB bioAdvances · 2025Article
- Sex-Specific Characteristics of Perivascular Fat in Aortic Aneurysms.Journal of clinical medicine · 2025Review
- U-Shaped Association of Visceral Fat Area With Diabetic Peripheral Neuropathy.Journal of diabetes research · 2025Article
- Markers of tumor-associated macrophages and microglia exhibit high intratumoral heterogeneity in human glioblastoma tissue.Oncoimmunology · 2024Article
- Physiology and Pathobiology of Perivascular Adipose Tissue: Inflammation-based Atherogenesis.Physiological research · 2024Review
- Effects of time-restricted feeding (TRF)-model of intermittent fasting on adipose organ: a narrative review.Eating and weight disorders : EWD · 2024Review
- Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsets.Scientific reports · 2024Article
- Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots.Life metabolism · 2023Article
- The Role of Cdc42 in the Insulin and Leptin Pathways Contributing to the Development of Age-Related Obesity.Nutrients · 2023Review
- Exploring the Diversity of Visceral, Subcutaneous and Perivascular Adipose Tissue in a Vascular Surgery Population.Journal of cardiovascular development and disease · 2023Article
- Cholesterol efflux and macrophage polarization in human adipose tissue.Physiological research · 2022Article
- Rapid Drop in Coronary Heart Disease Mortality in Czech Male Population-What Was Actually behind It?Biomedicines · 2022Article
- Adipocyte size, adipose tissue fibrosis, macrophage infiltration and disease risk are different in younger and older individuals with childhood versus adulthood onset obesity.International journal of obesity (2005) · 2022Article
- Immune Modulation of Adipocyte Mitochondrial Metabolism.Endocrinology · 2022Article
- Elevated CTSL Gene Expression Correlated with Proinflammatory Cytokines in Omental Adipose Tissue of Patients with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsMacrophages play important roles in adipose tissue inflammation and its consequences. Unfortunately, a detailed description of the macrophage phenotypes in different human adipose tissues is not available. SUBJECTS AND
methodsSubcutaneous, visceral and perivascular adipose tissues were obtained from 52 living kidney donors during live donor nephrectomy. Stromal vascular fractions were isolated, and the macrophage phenotypes were analyzed by flow cytometry using surface markers (CD14, CD16, CD36, and CD163).
resultsIn addition to CD16 positivity, pro-inflammatory macrophages also display high scavenger receptor CD36 expression. The great majority of CD16 negative macrophages express the anti-inflammatory CD163 marker. The presence of pro-inflammatory macrophages was almost twice as high in visceral (p < 0.0001) and perivascular (p < 0.0001) adipose tissues than in subcutaneous tissue. This difference was substantially more pronounced in the postmenopausal women subgroup, consequentlly, the total difference was driven by this subgroup.
conclusionWe obtained detailed information about M1 and M2 macrophage phenotypes in human adipose tissue. The visceral and perivascular adipose tissues had substantially higher pro-inflammatory characteristics than the subcutaneous tissue. The higher proportion of pro-inflammatory macrophages in the visceral adipose tissue of postmenopausal women might be related to an increased cardiovascular risk.
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