ArticlePloS one2016
Symptomatic and Asymptomatic Neurological Complications of Infective Endocarditis: Impact on Surgical Management and Prognosis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272724 (French National Observatory on Infective Endocarditis), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
French National Observatory on Infective Endocarditis
Who cites it
23 citing papers in PubMed.
- Neurological Complications and Surgical Outcomes in Infective Endocarditis.Journal of the American Heart Association · 2026Article
- Mind the Gap: Inadequate Performance of Embolic Risk Scores in Infective Endocarditis.Open forum infectious diseases · 2026Article
- Neurological Complications in Surgical Patients with Left-Sided Infective Endocarditis: Risk Factors, Prognosis, and Surgical Timing.Journal of cardiovascular development and disease · 2025Article
- Review
- Transthoracic Echocardiography in Assessing Patients with Suspected Infective Endocarditis (TEASE): An Exploratory Study.Journal of clinical medicine · 2025Article
- The Evolving Landscape of Infective Endocarditis: Difficult-to-Treat Resistance Bacteria and Novel Diagnostics at the Foreground.Journal of clinical medicine · 2025Review
- Embolic risk management in infective endocarditis: predicting the 'embolic roulette'.Open heart · 2025Review
- Prognostic factors for long-term mortality after surgery of left-sided infective endocarditis.PloS one · 2025Article
- Infective endocarditis in a Finnish tertiary care hospital: from etiology to embolic events.Annals of medicine · 2024Article
- The Impact of Neurological Complications in Endocarditis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- [Inflammatory causes of stroke-Diagnostics and treatment].Der Nervenarzt · 2024Article
- Aortic and Mitral Valve Endocarditis-Simply Left-Sided Endocarditis or Different Entities Requiring Individual Consideration?-Insights from the CAMPAIGN Database.Journal of clinical medicine · 2024Article
- Impact of postoperative cerebral complications in acute infective endocarditis: a retrospective single-center study.Journal of cardiothoracic surgery · 2024Article
- Embolic Events in Infective Endocarditis: A Comprehensive Review.Reviews in cardiovascular medicine · 2024Review
- Review
- Rothia dentocariosa endocarditis with brain abscess and splenic abscess: case report and brief review.Frontiers in cardiovascular medicine · 2024Article
- Optimal Timing for Cardiac Surgery in Infective Endocarditis with Neurological Complications: A Narrative Review.Journal of clinical medicine · 2022Review
- Neurological Complications in Active Left-Sided Infective Endocarditis Requiring Early Surgery.Frontiers in cardiovascular medicine · 2021Article
- Long-term Outcome of Neurological Complications after Infective Endocarditis.Scientific reports · 2020Observational
- Learning From Controversy: Contemporary Surgical Management of Aortic Valve Endocarditis.Clinical Medicine Insights. Cardiology · 2020Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSymptomatic neurological complications (NC) are a major cause of mortality in infective endocarditis (IE) but the impact of asymptomatic complications is unknown. We aimed to assess the impact of asymptomatic NC (AsNC) on the management and prognosis of IE.
methodsFrom the database of cases collected for a population-based study on IE, we selected 283 patients with definite left-sided IE who had undergone at least one neuroimaging procedure (cerebral CT scan and/or MRI) performed as part of initial evaluation.
resultsAmong those 283 patients, 100 had symptomatic neurological complications (SNC) prior to the investigation, 35 had an asymptomatic neurological complications (AsNC), and 148 had a normal cerebral imaging (NoNC). The rate of valve surgery was 43% in the 100 patients with SNC, 77% in the 35 with AsNC, and 54% in the 148 with NoNC (p<0.001). In-hospital mortality was 42% in patients with SNC, 8.6% in patients with AsNC, and 16.9% in patients with NoNC (p<0.001). Among the 135 patients with NC, 95 had an indication for valve surgery (71%), which was performed in 70 of them (mortality 20%) and not performed in 25 (mortality 68%). In a multivariate adjusted analysis of the 135 patients with NC, age, renal failure, septic shock, and IE caused by S. aureus were independently associated with in-hospital and 1-year mortality. In addition SNC was an independent predictor of 1-year mortality.
conclusionsThe presence of NC was associated with a poorer prognosis when symptomatic. Patients with AsNC had the highest rate of valve surgery and the lowest mortality rate, which suggests a protective role of surgery guided by systematic neuroimaging results.
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