Evidence map›Paper›PMID 27400195›Full record

ArticleClinical and experimental immunology2016

Interleukin (IL)-39 [IL-23p19/Epstein-Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice.

X Wang, X Liu, Y Zhang, Z Wang, G Zhu, G Han, G Chen, C Hou, T Wang, N Ma and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 63 citations in OpenAlex.

  1. Trial
  2. Interleukin-39 is a Prognostic Biomarker and Therapy Target for Sepsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

X WangLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China. wang_renxi@yahoo.com.
X LiuLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
Y ZhangLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
Z WangLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
G ZhuLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
G HanLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
G ChenLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
C HouLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
T WangCollege of Pharmacy, Henan University, Kaifeng, China.
N MaDepartment of Rheumatology, First Hospital of Jilin University, Changchun, China.
B ShenLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
Y LiLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
H XiaoLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China. yinher2001@yahoo.com.
R WangLaboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
Institute of Basic Medical Sciences of the Chinese Academy of Medical SciencesHenan University · CN307th Hospital of Chinese People’s Liberation Army · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin (IL)-12 family cytokines play critical roles in autoimmune diseases. Our previous study has shown that IL-23p19 and Epstein-Barr virus-induced 3 (Ebi3) form a new IL-12 family heterodimer, IL-23p19/Ebi3, termed IL-39, and knock-down of p19 or Ebi3 reduced diseases by transferred GL7

Indexed as

AnimalsAntigens, DifferentiationB-Cell Activating FactorBiomarkersB-Lymphocyte SubsetsCD11b AntigenCell DifferentiationCell LineCells, CulturedFemaleGene ExpressionInterleukin-23 Subunit p19MiceMice, Inbred MRL lprMice, KnockoutMinor Histocompatibility Antigensantigen GL7Antigens, DifferentiationB-Cell Activating FactorBiomarkersCD11b AntigenEbi3 protein, mouseInterleukin-23 Subunit p19Minor Histocompatibility AntigensReceptors, CytokineSTAT3 Transcription Factorautoimmune diseasesBAFFIL-39lupusneutrophils

Identifiers

PMID27400195
PMCPMC5054574
OpenAlexW2485577998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.