ArticleBiology2016
Phenotype as Agent for Epigenetic Inheritance.
Article in Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- Comparative Analysis ofGenes · 2026Article
- Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology.Cellular and molecular life sciences : CMLS · 2023Review
- Cellular and Natural Viral Engineering in Cognition-Based Evolution.Communicative & integrative biology · 2023Review
- From Molecular Recognition to the "Vehicles" of Evolutionary Complexity: An Informational Approach.International journal of molecular sciences · 2021Review
- Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution.Cells · 2021Review
- Reappraising the exteriorization of the mammalian testes through evolutionary physiology.Communicative & integrative biology · 2019Review
- The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism.Progress in biophysics and molecular biology · 2017Review
- A systematic approach to cancer: evolution beyond selection.Clinical and translational medicine · 2017Article
- The Cell as the First Niche Construction.Biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The conventional understanding of phenotype is as a derivative of descent with modification through Darwinian random mutation and natural selection. Recent research has revealed Lamarckian inheritance as a major transgenerational mechanism for environmental action on genomes whose extent is determined, in significant part, by germ line cells during meiosis and subsequent stages of embryological development. In consequence, the role of phenotype can productively be reconsidered. The possibility that phenotype is directed towards the effective acquisition of epigenetic marks in consistent reciprocation with the environment during the life cycle of an organism is explored. It is proposed that phenotype is an active agent in niche construction for the active acquisition of epigenetic marks as a dominant evolutionary mechanism rather than a consequence of Darwinian selection towards reproductive success. The reproductive phase of the life cycle can then be appraised as a robust framework in which epigenetic inheritance is entrained to affect growth and development in continued reciprocal responsiveness to environmental stresses. Furthermore, as first principles of physiology determine the limits of epigenetic inheritance, a coherent justification can thereby be provided for the obligate return of all multicellular eukaryotes to the unicellular state.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.