Evidence map›Paper›PMID 27399777›Full record

ArticleToxins2016

Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms.

Jordan Debono, Chip Cochran, Sanjaya Kuruppu, Amanda Nouwens, Niwanthi W Rajapakse, Minami Kawasaki, Kelly Wood, James Dobson, Kate Baumann, Mahdokht Jouiaei and 7 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Jordan DebonoVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. jordan.debono@uqconnect.edu.au.
Chip CochranDepartment of Earth and Biological Sciences, Loma Linda University, Loma Linda, CA 92350, USA. rcochran@llu.edu.
Sanjaya KuruppuDepartment of Biochemistry & Molecular Biology, Biomedical Discovery Institute, Monash University, Clayton, VIC 3800, Australia. sanjaya.kuruppu@monash.edu.
Amanda NouwensSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia. a.nouwens@uq.edu.au.
Niwanthi W RajapakseBaker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia. niwanthi.rajapakse@bakeridi.edu.au.
Minami KawasakiAquatic Animal Health, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072 Australia. minami.kawasaki@uqconnect.edu.au.
Kelly WoodVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. gone2@westnet.com.au.
James DobsonVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. james.dobson@uqconnect.edu.au.
Kate BaumannVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. kate.baumann@uqconnect.edu.au.
Mahdokht JouiaeiVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. mahdokht.jouiaei@gmail.com.
Timothy N W JacksonVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. tnwjackson@gmail.com.
Ivan KoludarovVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. jcoludar@gmail.com.
Dolyce LowVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. dol_yce@hotmail.com.
Syed A AliVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. dr.syedabidali@gmail.com.
A Ian SmithDepartment of Biochemistry & Molecular Biology, Biomedical Discovery Institute, Monash University, Clayton, VIC 3800, Australia. Ian.Smith@monash.edu.
Andrew BarnesAquatic Animal Health, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072 Australia.
Bryan G FryVenom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. bgfry@uq.edu.au.
The University of Queensland · AUMonash University · AUBaker Heart and Diabetes Institute · AULoma Linda University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledge gap, venom proteomics and toxin activity of species of Bothriechis, and Bothrops (including Bothriopsis) were investigated through established analytical methods. A combination of proteomics and bioactivity techniques was used to demonstrate a similar diversification of venom composition between large and small species within Bothriechis and Bothriopsis. Increasing our understanding of the evolution of complex venom cocktails may facilitate future biodiscoveries.

Indexed as

EcosystemEvolution, MolecularTreesAdaptation, PhysiologicalAnimalsBothropsCrotalid VenomsElectrophoresis, Gel, Two-DimensionalElectrophoresis, Polyacrylamide GelMass SpectrometryPhylogenyProteomicsReptilian ProteinsCrotalid VenomsReptilian Proteinsenzymeevolutionpit-vipervenom

Identifiers

PMID27399777
PMCPMC4963843
OpenAlexW2462452733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.