ArticleNutrients2016
Lactobacillus fermentum CRL1446 Ameliorates Oxidative and Metabolic Parameters by Increasing Intestinal Feruloyl Esterase Activity and Modulating Microbiota in Caloric-Restricted Mice.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07530575 (Biological Effects of the Consumption of Limosilactobacillus Fermentum CRL 1446 - CONICET in Volunteers With Cardiovascular Risk Factors), which is not on this map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biological Effects of the Consumption of Limosilactobacillus Fermentum CRL 1446 - CONICET in Volunteers With Cardiovascular Risk Factors
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Comparative analysis of risedronate and its regioisomers synthesized via microwave-assisted method: bone affinity, cytotoxicity, permeability, and therapeutic potential.Pharmacological reports : PR · 2025Article
- Calorie restriction mimetic drugs could favorably influence gut microbiota leading to lifespan extension.GeroScience · 2023Review
- Socioeconomic disparities in fertility treatments and associated likelihood of livebirth following in vitro fertilization.Archives of gynecology and obstetrics · 2023Article
- Calorie restriction ameliorates hyperglycemia, modulates the disordered gut microbiota, and mitigates metabolic endotoxemia and inflammation in type 2 diabetic rats.Journal of endocrinological investigation · 2023Article
- Screening and Characterization of Some Lactobacillaceae for Detection of Cholesterol-Lowering Activities.Probiotics and antimicrobial proteins · 2022Article
- Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases.Heliyon · 2022Article
- Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome.International journal of molecular sciences · 2022Review
- Temporal Dynamics of the Intestinal Microbiome Following Short-Term Dietary Restriction.Nutrients · 2022Article
- Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice.Nature communications · 2022Article
- The Therapeutic Role of Exercise and Probiotics in Stressful Brain Conditions.International journal of molecular sciences · 2022Review
- The microbiota composition drives personalized nutrition: Gut microbes as predictive biomarkers for the success of weight loss diets.Frontiers in nutrition · 2022Review
- Calorie Restriction as a New Treatment of Inflammatory Diseases.Advances in nutrition (Bethesda, Md.) · 2021Review
- Young at Gut-Turning Back the Clock with the Gut Microbiome.Microorganisms · 2021Review
- Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further.Frontiers in nutrition · 2021Review
- Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice.Frontiers in nutrition · 2021Article
- Probiotic Characterization of Cholesterol-Lowering Lactobacillus fermentum MJM60397.Probiotics and antimicrobial proteins · 2020Article
- Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases.Microorganisms · 2020Review
- Genome sequence of the potential probiotic eukaryote3 Biotech · 2020Article
- Nutraceuticals Inspiring the Current Therapy for Lifestyle Diseases.Advances in pharmacological sciences · 2019Review
- Calorie restriction and its impact on gut microbial composition and global metabolism.Frontiers of medicine · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine whether the administration of the feruloyl esterase (FE)-producing strain Lactobacillus fermentum CRL1446 enhances metabolic and oxidative parameters in caloric-restricted (CR) mice. Balb/c male mice were divided into ad libitum fed Group (ALF Group), CR diet Group (CR Group) and CR diet plus L. fermentum Group (CR-Lf Group). CR diet was administered during 45 days and CRL1446 strain was given in the dose of 10⁸ cells/mL/day/mouse. FE activity was determined in intestinal mucosa and content at Day 1, 20 and 45. Triglyceride, total cholesterol, glucose, thiobarbituric acid reactive substances (TBARS) levels and glutathione reductase activity were determined in plasma. Gut microbiota was evaluated by high-throughput sequencing of 16S rRNA gene amplicons. At Day 45, total intestinal FE activity in CR-Lf Group was higher (p = 0.020) than in CR and ALF groups and an improvement in both metabolic (reductions in triglyceride (p = 0.0025), total cholesterol (p = 0.005) and glucose (p < 0.0001) levels) and oxidative (decrease of TBARS levels and increase of plasmatic glutathione reductase activity (p = 0.006)) parameters was observed, compared to ALF Group. CR diet increased abundance of Bacteroidetes and CRL1446 administration increased abundance of Bifidobacterium and Lactobacillus genus. L. fermentun CRL1446 exerted a bifidogenic effect under CR conditions.
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Registered trials
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