ArticleMolecules (Basel, Switzerland)2016
Cytotoxic Alkaloids from the Stem of Xylopia laevigata.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
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- Bioactivities and Phytochemical Profiling ofACS omega · 2025Article
- Enantioselective Complexation of Xylopinine: A Cyclodextrin-Assisted CE and NMR Study.International journal of molecular sciences · 2025Article
- Effect of Auxins on the Accumulation of Alkaloids in UngraftedMolecules (Basel, Switzerland) · 2025Article
- Biological Potential of Oxoglaucine in Medicine for the Treatment of Human Disorders: An Update on Pharmacological Activities and Related Molecular Mechanism.Recent advances in anti-infective drug discovery · 2025Review
- Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application.Journal of advanced research · 2024Review
- Antibacterial and Antibiofilm Potential of Ethanolic Extracts ofPlants (Basel, Switzerland) · 2024Article
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- The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke.Molecules (Basel, Switzerland) · 2022Review
- Acaricidal Activity of Annonaceae Plants for Dermanyssus gallinae (Acari: Dermanyssidae) and Metabolomic Profile by HPLC-MS/MS.Neotropical entomology · 2021Article
- Benzylated Dihydroflavones and Isoquinoline-Derived Alkaloids from the Bark ofMolecules (Basel, Switzerland) · 2021Article
- Article
- Myrtenol Attenuates MRSA Biofilm and Virulence by SuppressingFrontiers in microbiology · 2019Article
- Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells.Scientific reports · 2018Article
- The norpurpureine alkaloid fromCellular & molecular biology letters · 2018Article
- Xylopine Induces Oxidative Stress and Causes GOxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xylopia laevigata (Annonaceae), known locally as "meiú" or "pindaíba", is widely used in folk medicine in Northeastern Brazil. In the present work, we performed phytochemical analyses of the stem of X. laevigata, which led to the isolation of 19 alkaloids: (-)-roemerine, (+)-anonaine, lanuginosine, (+)-glaucine, (+)-xylopine, oxoglaucine, (+)-norglaucine, asimilobine, (-)-xylopinine, (+)-norpurpureine, (+)-N-methyllaurotetanine, (+)-norpredicentrine, (+)-discretine, (+)-calycinine, (+)-laurotetanine, (+)-reticuline, (-)-corytenchine, (+)-discretamine and (+)-flavinantine. The in vitro cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuclear cells (PBMCs) was tested using the Alamar Blue assay. Lanuginosine, (+)-xylopine and (+)-norglaucine had the highest cytotoxic activity. Additionally, the pro-apoptotic effects of lanuginosine and (+)-xylopine were investigated in HepG2 cells using light and fluorescence microscopies and flow cytometry-based assays. Cell morphology consistent with apoptosis and a marked phosphatidylserine externalization were observed in lanuginosine- and (+)-xylopine-treated cells, suggesting induction of apoptotic cell death. In addition, (+)-xylopine treatment caused G₂/M cell cycle arrest in HepG2 cells. These data suggest that X. laevigata is a potential source for cytotoxic alkaloids.
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