ReviewMolecules (Basel, Switzerland)2016
Marine Natural Products as Models to Circumvent Multidrug Resistance.
Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Isolation and structure elucidation of the compounds from Teucrium hyrcanicum L. and the investigation of cytotoxicity, antioxidant activity, and protective effect on hydrogen peroxide-induced oxidative stress.BMC complementary medicine and therapies · 2023Article
- Bioprospecting the microbiome of Red Sea Atlantis II brine pool for peptidases and biosynthetic genes with promising antibacterial activity.Microbial cell factories · 2022Article
- Cancer Cell Inhibiting Sea Cucumber (Nutrients · 2022Article
- Remodeling tumor microenvironment with natural products to overcome drug resistance.Frontiers in immunology · 2022Review
- Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants.Marine drugs · 2021Article
- Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides.Molecules (Basel, Switzerland) · 2021Review
- The Phylum Bryozoa: From Biology to Biomedical Potential.Marine drugs · 2020Review
- Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives.Marine drugs · 2019Review
- Article
- Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool.Microbial cell factories · 2019Article
- The Effects of Synthetically Modified Natural Compounds on ABC Transporters.Pharmaceutics · 2018Review
- Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights.Redox biology · 2018Article
- Ascidian Toxins with Potential for Drug Development.Marine drugs · 2018Review
- Expression of genes and proteins of multidrug resistance in gastric cancer cells treated with resveratrol.Oncology letters · 2018Article
- Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.The AAPS journal · 2017Review
- Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives.Marine drugs · 2017Review
- Special Issue: New Approaches to Counteract Drug Resistance in Cancer.Molecules (Basel, Switzerland) · 2016Article
- The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy.Frontiers in pharmacology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug resistance (MDR) to anticancer drugs is a serious health problem that in many cases leads to cancer treatment failure. The ATP binding cassette (ABC) transporter P-glycoprotein (P-gp), which leads to premature efflux of drugs from cancer cells, is often responsible for MDR. On the other hand, a strategy to search for modulators from natural products to overcome MDR had been in place during the last decades. However, Nature limits the amount of some natural products, which has led to the development of synthetic strategies to increase their availability. This review summarizes the research findings on marine natural products and derivatives, mainly alkaloids, polyoxygenated sterols, polyketides, terpenoids, diketopiperazines, and peptides, with P-gp inhibitory activity highlighting the established structure-activity relationships. The synthetic pathways for the total synthesis of the most promising members and analogs are also presented. It is expected that the data gathered during the last decades concerning their synthesis and MDR-inhibiting activities will help medicinal chemists develop potential drug candidates using marine natural products as models which can deliver new ABC transporter inhibitor scaffolds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.