ArticlePloS one2016
Development of a Korean Fracture Risk Score (KFRS) for Predicting Osteoporotic Fracture Risk: Analysis of Data from the Korean National Health Insurance Service.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Predictive value of machine learning on fracture risk in osteoporosis: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Alcohol Consumption and Risk of Fractures: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Prevalence of osteoporosis and incidence of related fractures in developed economies in the Asia Pacific region: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- Development of Simple Assessment tool for predict imminent risk of Fracture in Elderly women.The Korean journal of internal medicine · 2026Article
- Construction and verification of risk prediction model of osteoporotic fractures in patients with osteoporosis in China.Frontiers in public health · 2024Article
- Development and validation of common data model-based fracture prediction model using machine learning algorithm.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- The surgical management trends of osteoporotic vertebral compression fractures: 5-year experience in one institution.Scientific reports · 2022Article
- Prediction Models for Osteoporotic Fractures Risk: A Systematic Review and Critical Appraisal.Aging and disease · 2022Review
- Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea.International journal of environmental research and public health · 2022Article
- Development and validation of a nomogram for predicting stroke risk in rheumatoid arthritis patients.Aging · 2021Article
- Long-Term Treatment of Postmenopausal Osteoporosis.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea.Frontiers in endocrinology · 2021Article
- Effects of Systemic Glucocorticoid Use on Fracture Risk: A Population-Based Study.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- Incidence and Management Trends of Osteoporotic Vertebral Compression Fractures in South Korea: A Nationwide Population-Based Study.Asian spine journal · 2020Article
- Gender difference in colorectal cancer indicators for exercise interventions: the National Health Insurance Sharing Service-Derived Big Data Analysis.Journal of exercise rehabilitation · 2019Article
- Associated Factors for Osteoporosis and Fracture in Chinese Elderly.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Gender differences in anti-osteoporosis drug treatment after osteoporotic fractures.Journal of bone and mineral metabolism · 2019Article
- Effect of improved medication adherence on health care costs in osteoporosis patients.Medicine · 2018Observational
- The Impact of Educational Interventions on Osteoporosis Knowledge among Korean Osteoporosis Patients.Journal of bone metabolism · 2018Article
- Review of Epidemiology, Diagnosis, and Treatment of Osteosarcopenia in Korea.Journal of bone metabolism · 2018Review
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Authors and funding
7 authors at 7 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAsian-specific prediction models for estimating individual risk of osteoporotic fractures are rare. We developed a Korean fracture risk prediction model using clinical risk factors and assessed validity of the final model.
methodsA total of 718,306 Korean men and women aged 50-90 years were followed for 7 years in a national system-based cohort study. In total, 50% of the subjects were assigned randomly to the development dataset and 50% were assigned to the validation dataset. Clinical risk factors for osteoporotic fracture were assessed at the biennial health check. Data on osteoporotic fractures during the follow-up period were identified by ICD-10 codes and the nationwide database of the National Health Insurance Service (NHIS).
resultsDuring the follow-up period, 19,840 osteoporotic fractures were reported (4,889 in men and 14,951 in women) in the development dataset. The assessment tool called the Korean Fracture Risk Score (KFRS) is comprised of a set of nine variables, including age, body mass index, recent fragility fracture, current smoking, high alcohol intake, lack of regular exercise, recent use of oral glucocorticoid, rheumatoid arthritis, and other causes of secondary osteoporosis. The KFRS predicted osteoporotic fractures over the 7 years. This score was validated using an independent dataset. A close relationship with overall fracture rate was observed when we compared the mean predicted scores after applying the KFRS with the observed risks after 7 years within each 10th of predicted risk.
conclusionWe developed a Korean specific prediction model for osteoporotic fractures. The KFRS was able to predict risk of fracture in the primary population without bone mineral density testing and is therefore suitable for use in both clinical setting and self-assessment. The website is available at http://www.nhis.or.kr.
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